Influence of corticosteroids on glycogen content and steroid 11-reductase activity in lung and liver of the fetal and newborn rat.
Influence of corticosteroids on glycogen content and steroid 11-reductase activity in lung and liver of the fetal and newborn rat.
复制标题
皮质类固醇对胎鼠和新生大鼠肺和肝中糖原含量和类固醇11-还原酶活性的影响。
DOI：
10.1159/000241600
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
E. Vreeken
中科院分区：
文献类型：
--
作者：
Smith Bt;Tanswell Ak;D. Minshall;W. N. Bogues;E. Vreeken
肺和肝糖原和皮质类固醇11-还原酶活性进行了研究，在胎儿和新生大鼠。肺糖原含量在妊娠第20天达到峰值，而肝糖原含量一般较低，达到峰值较晚。无论是出生前还是出生后，贝妥英钠给药均导致肺糖原降低和肝糖原升高。在肺和肝，皮质类固醇11-还原酶活性呈逆发展模式的糖原含量。倍他米松升高肺皮质类固醇11-还原酶活性，降低肝脏活性。在肺和肝中，糖原含量和皮质类固醇11-还原酶活性在发育过程中和糖皮质激素治疗后密切相关。
Lung and liver glycogen and corticosteroid 11-reductase activity were studied in fetal and neonatal rats. Glycogen content peaked in the lung on day 20 of gestation, while hepatic glycogen content was generally lower and peaked later. Both pre- and postnatally, betamethasone administration resulted in lowered pulmonary and elevated hepatic glycogen. In both lung and liver, corticosteroid 11-reductase activity showed an inverse developmental pattern to glycogen content. Betamethasone elevated pulmonary corticosteroid 11-reductase activity and lowered hepatic activity. In lung and liver, glycogen content and corticosteroid 11-reductase activity are tightly linked during development and following glucocorticoid therapy.