Enantioselective Construction of Functionalized Thiopyrano-lndole Annulated Heterocycles via a Formal Thio [3+31-Cyclization
Enantioselective Construction of Functionalized Thiopyrano-lndole Annulated Heterocycles via a Formal Thio [3+31-Cyclization
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DOI：
10.1021/ol503210q
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发表时间：
2015-01-02
期刊：
影响因子：
5.2
通讯作者：
Wang, Xing-Wang
中科院分区：
文献类型：
--
作者：
Chen, Xiang;Qi, Zheng-Hang;Wang, Xing-Wang
A formal thio [3 + 3]-cyclization catalyzed by a DPEN-derived chiral thiourea has been reported for the construction of optically active thiopyrano-indole annulated heterocyclic compounds in high yields with excellent enantioselectivities. The high reactivity between indoline-2-thione (keto-S) and 2-benzylidenemalononitrile has also been supported by density functional theory (DFT) calculations.
