Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function
Left atrial relaxation and left ventricular systolic function determine left atrial reservoir function
复制标题
DOI：
10.1161/01.cir.100.4.427
复制
发表时间：
1999-07-27
期刊：
影响因子：
37.8
通讯作者：
Glantz, SA
中科院分区：
文献类型：
--
作者：
Barbier, P;Solomon, SB;Glantz, SA
背景：左房（LA）储血池功能的决定因素及其对左室（LV）功能的影响尚未被量化。方法和结果：在心包开放、有节奏（70和90 bpm）的左室局部缺血（左冠状动脉前降缩）猪模型中，使用高保真的左室、左室和右室压力记录，我们使用二维自动边界检测超声心动图、左室压力区环路和多普勒传递血流获得左室区域。我们计算了LV tau， LA松弛（a-x压力差除以时间，由压力归一化）和刚度（v回路的x和v压力点之间的斜率）。通过多元回归分析确定了LA总储层的决定因素（最大-最小面积，cm(2)）。不同的平均LA面积增加速率确定了2个连续的储层阶段（早期快速和后期缓慢）。缺血时，左室长轴缩短（LAS，左室基底收缩下降）和左室蓄水池面积变化减少(7.3+/-0.3 [SEM]比5.6+/-0.3 cm(2)， P
Background-Determinants of left atrial (LA) reservoir function and its influence on left ventricular (LV) function have not been quantified.Methods and Results-In an open-pericardium, paced (70 and 90 bpm) pig model of LV regional ischemia (left anterior descending coronary constriction), with high-fidelity LV, LA, and RV pressure recordings, we obtained the LA area with 2D automated border detection echocardiography, LA pressure-area loops, and Doppler transmitral flow. We calculated LV tau, LA relaxation (a-x pressure difference divided by time, normalized by a pressure), and stiffness (slope between x and v pressure points of v loop). Determinants of total LA reservoir (maximum-minimum area, cm(2)) were identified by multiple regression analysis. Different mean rates of LA area increase identified 2 consecutive (early rapid and late slow) reservoir phases. During ischemia, LV long-axis shortening (LAS, LV base systolic descent) and LA reservoir area change decreased (7.3+/-0.3 [SEM] versus 5.6+/-0.3 cm(2), P