Decreased Lempel-Ziv complexity in Alzheimer's disease patients' magnetoencephalograms
Decreased Lempel-Ziv complexity in Alzheimer's disease patients' magnetoencephalograms
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DOI：
10.1109/iembs.2005.1615472
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Carlos Gómez;R. Hornero;D. Abásolo;M. López;Alberto Fernández
中科院分区：
文献类型：
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作者：
Carlos Gómez;R. Hornero;D. Abásolo;M. López;Alberto Fernández
本研究的目的是利用Lempel-Ziv（LZ）复杂度研究阿尔茨海默病（AD）患者脑磁图（MEG）的背景活动。我们用148通道全头磁力计（MAGNES 2500 WH，4D Neuroimaging）在5分钟内记录了10例可能患有AD的患者和10例年龄匹配的对照受试者的MEG。选择无伪影时期进行非线性分析。在所有MEG通道中，AD患者的复杂性低于对照组。其中77例差异有统计学意义（P < 0.01）。这些初步结果表明，AD的认知功能障碍与大脑某些区域的复杂性降低有关
The aim of the present research is to study the magnetoencephalogram (MEG) background activity in patients with Alzheimer's disease (AD) using the Lempel-Ziv (LZ) complexity. We recorded the MEG with a 148-channel whole-head magnetometer (MAGNES 2500 WH, 4D Neuroimaging) in 10 patients with probable AD and 10 age-matched control subjects, during five minutes. Artefact-free epochs were selected for the non-linear analysis. In all MEG channels, the AD patients had lower complexity than control subjects. In 77 of them the differences were statistically significant (p < 0.01). These preliminary results suggest that cognitive dysfunction in AD is associated with a decreased complexity in certain regions of the brain