Simplified polymer mimics of cross-linking adhesive proteins
Simplified polymer mimics of cross-linking adhesive proteins
复制标题
DOI：
10.1021/ma0703002
复制
发表时间：
2007-05-29
期刊：
影响因子：
5.5
通讯作者：
Wilker, Jonathan J.
中科院分区：
文献类型：
--
作者：
Westwood, Glenn;Horton, Trinity N.;Wilker, Jonathan J.
海洋贻贝和藤壶通过沉积蛋白质的混合物然后交联这些聚合物以固化它们的粘合剂来将它们自身附着到表面。获得大量的这些生物材料用于应用开发已被证明是有问题的。在这里，我们提出了合成，反应性和粘合剂的简化聚合物模拟生物粘合剂的特性。聚苯乙烯主链用于代替蛋白质聚酰胺链。交联邻苯二酚基团附加到聚苯乙烯上，以模拟贻贝粘附蛋白中的关键交联基团3，4-二羟基苯乙烯（DOPA）。我们发现，聚[（3，4-二甲氧基苯乙烯）-共-苯乙烯]聚合物表现出固化类似的蛋白质后，他们被建模。苯乙烯-邻苯二酚共聚物在交联时也显示出增强的粘附性。这份报告展示了一种还原论的方法，以开发新的聚合物材料的基础上，从自然界的原则。
Marine mussels and barnacles attach themselves to surfaces by depositing mixtures of proteins and then cross-linking these polymers for curing of their adhesive. Obtaining large quantities of these biological materials for applications development has proven to be problematic. Here we present the synthesis, reactivity, and adhesive characteristics of simplified polymer mimics of bioadhesives. A polystyrene backbone is used to take the place of the protein polyamide chain. Cross-linkable catechol groups are appended to the polystyrene in order to mimic 3,4-dihydroxystyrene (DOPA), the key cross-linking group in mussel adhesive proteins. We show that poly[(3,4-dimethoxystyrene)-co-styrene] polymers exhibit curing analogous to that of the proteins after which they were modeled. The styrene-catechol copolymers also display enhanced adhesion upon cross-linking. This report demonstrates a reductionist approach to developing new polymeric materials on the basis of principles learned from nature.