Association analysis of δ‐opioid receptor gene polymorphisms in methamphetamine dependence/psychosis
Association analysis of δ‐opioid receptor gene polymorphisms in methamphetamine dependence/psychosis
复制标题
δ-阿片受体基因多态性与甲基苯丙胺依赖/精神病的关联分析
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
I. Sora
中科院分区：
文献类型：
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作者：
Hideaki Kobayashi;H. Hata;H. Ujike;M. Harano;T. Inada;T. Komiyama;M. Yamada;Y. Sekine;N. Iwata;M. Iyo;N. Ozaki;M. Itokawa;Maki Naka;S. Ide;K. Ikeda;Y. Numachi;I. Sora
应用δ阿片受体基因多态性与甲基苯丙胺(MAP)依赖/精神病的关联分析，探讨OPRD1基因在甲基苯丙胺(MAP)成瘾中的作用。对日本MAP依赖/精神病患者的DNA样本进行分析，以发现OPRD1基因外显子和外显子-内含子边界的多态。发现1个新的单核苷酸多态(SNP)位于第1内含子，2个SNP位于第3外显子。外显子3的两个SNP处于连锁不平衡状态。在对照组(n = 2 6 0)和MAP依赖/精神病患者(n = 170)中，这些SNPs的基因频率和等位基因频率均无显著差异。使用三个SNPs进行的全球分析和对临床参数的亚类分析也显示没有显著差异。这些结果表明，OPRD1基因变异可能不是导致依赖/精神病易感性的一个因素。©2006 Wiley-Liss，Inc.
The role of the δ‐opioid receptor (OPRD1) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon–intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis. © 2006 Wiley‐Liss, Inc.
DOI：
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发表时间：
1998-07
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
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作者：
S. Negus;M. B. Gatch;Nancy K. Mello;Xiaoyan Zhang;Kenner C Rice
通讯作者：
S. Negus;M. B. Gatch;Nancy K. Mello;Xiaoyan Zhang;Kenner C Rice