Quantitative carcinogenesis in man: solar ultraviolet B dose dependence of skin cancer in Maryland watermen.
Quantitative carcinogenesis in man: solar ultraviolet B dose dependence of skin cancer in Maryland watermen.
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人类的定量致癌作用：马里兰州水工皮肤癌的太阳紫外线 B 剂量依赖性。
DOI：
10.1093/jnci/81.24.1910
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Taylor,HR
中科院分区：
文献类型：
--
作者：
Strickland,PT;Vitasa,BC;West,SK;Rosenthal,FS;Emmett,EA;Taylor,HR
皮肤癌是人类最常见的癌症形式，主要发生在身体暴露于阳光的区域。在一项对808名马里兰州白人水手的研究中，我们研究了非黑色素瘤皮肤癌的患病率与年龄和暴露于太阳紫外线B（UVB）辐射的关系。对于每个研究对象，计算了16岁以后每年的太阳UVB辐射暴露量。我们通过将详细的职业史与实验室和现场测量相结合来获得用于此分析的数据。分析了三种主要类型的非黑色素瘤皮肤肿瘤的患病率：鳞状细胞癌（SCC）、基底细胞癌（BCC）和光化性角化病（AK）。年平均暴露于UVB辐射与SCC的患病率密切相关，但与BCC或AK的患病率无关。这一发现与UVB辐射年暴露量高的人诱导BCC和AK的剂量饱和（剂量-反应关系的平台期）一致。此外，两个小组显然hypersenseptible个人目前在人口。一组患有SCC，尽管每年暴露于UVB辐射较低，另一组患有多发性皮肤癌，尽管平均暴露于UVB辐射。[J Natl Cancer Inst 81：1910-1913，1989]。
Skin cancer is the most common form of cancer in humans and occurs primarily on sun-exposed areas of the body. In a study of 808 Caucasian Maryland watermen, we examined the prevalence of nonmelanoma skin cancer in relation to age and exposure to solar ultraviolet B (UVB) radiation. For each study subject, the exposure to solar UVB radiation for each year of life after the age of 16 years was calculated. We obtained the data for this analysis by combining a detailed occupational history with laboratory and field measurements. Prevalence of the three major types of nonmelanoma skin neoplasms was analyzed: squa-mous cell carcinoma (SCC), basal cell carcinoma (BCC), and actinic kerato-sis (AK). Average annual exposure to UVB radiation was strongly correlated with the prevalence of SCC, but not with the prevalence of BCC or AK. This finding is consistent with dose saturation (plateau in dose-response relationship) for the induction of BCC and AK in humans with high annual exposure to UVB radiation. In addition, two small groups of apparently hypersus-ceptible individuals were present in the population. One group had SCC despite low annual exposure to UVB radiation, and the other group had multiple skin cancers despite average exposure to UVB radiation. [J Natl Cancer Inst 81: 1910–1913, 1989].