Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors
Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors
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DOI：
10.1111/j.0303-6979.2004.00432.x
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发表时间：
2004-01-01
影响因子：
6.7
通讯作者：
Melloni, C
中科院分区：
文献类型：
--
作者：
Montebugnoli, L;Servidio, D;Melloni, C
目的：为了评估口腔健康不良和冠心病（CHD）和全身炎症和止血因素之间的关系在意大利population.Material和Methods：研究人群包括63名男性，年龄在40-65岁，证实冠心病和50名对照组相匹配的年龄，地理区域，和社会经济地位。使用四种不同的牙科指数（总牙科指数（TDI），全景断层扫描评分，临床牙周总和评分（CPSS），临床和放射学总和评分（CRSS））的口腔状况的详细描述。采集血液样本用于测量以下CHD危险因素：血清总胆固醇、甘油三酯、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇和葡萄糖;一系列炎症的系统性标志物（C-反应蛋白、白细胞、纤维蛋白原、同型半胱氨酸）及一系列止血因子（血管性血友病因子、纤维蛋白D-二聚体、凝血酶原片段F1.2、纤溶酶原激活物抑制剂I型（派-1）和血清抗体）结果：校正所有冠心病危险因素后的多因素Logistic回归分析显示，冠心病与抗氧化低密度脂蛋白（抗氧化低密度脂蛋白）的相关性有统计学意义（p
Objectives: To assess the relationship between poor oral health and coronary heart disease (CHD) and systemic inflammatory and haemostatic factors in an Italian population.Material and Methods: The study population consisted of 63 males aged 40-65 years with proven CHD and 50 controls matched for age, geographic area, and socioeconomic status. A detailed description of their oral status was given using four different dental indices (total dental index (TDI), panoramic tomography score, clinical periodontal sum score (CPSS), and clinical and radiographic sum score (CRSS)). Blood samples were taken for measurement of the following CHD risk factors: serum total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and glucose; a series of systemic markers of inflammation (C-reactive protein, leucocytes, fibrinogen, homocysteine) and a series of haemostatic factors (von Willebrand factor, fibrin D-dimer, prothrombinic fragment F1.2, plasminogen activator inhibitor type I (PAI-1), and serum antibodies) against oxidized LDL (anti-Ox-LDL).Results: Multiple logistic regression adjusted for all risk factors for CHD showed statistically significant relationships (p