THE ZONES OF DISCONTINUITY IN THE HUMAN LENS - DEVELOPMENT AND DISTRIBUTION WITH AGE
THE ZONES OF DISCONTINUITY IN THE HUMAN LENS - DEVELOPMENT AND DISTRIBUTION WITH AGE
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DOI：
10.1016/0042-6989(94)90267-4
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发表时间：
1994-11-01
期刊：
影响因子：
1.8
通讯作者：
KUSZAK, JR
中科院分区：
文献类型：
--
作者：
KORETZ, JF;COOK, CA;KUSZAK, JR
对 100 名年龄在 18 岁至 70 岁之间的正视人类受试者的晶状体的 Scheimpflug 图像进行的统计分析证实，特定的不连续区域是晶状体发育和生长的函数。 40 岁及以后，在晶状体前皮质和后晶状体皮质内会看到多达四个界限分明且互补的区域。前皮质不连续区的内边缘的位置相对于晶状体的中央沟进行表征。距中央沟的距离依次为 1.094、1.415、1.695 和 1.994 (+/-0.11 mm)。由于成人晶状体的核厚度与年龄无关，并且皮质生长速率已被表征，因此区域内边缘的位置表明了它们起源的年龄；这些年龄分别为 4 岁（+/-1 岁）、9 岁（+/-2 岁）、19 岁（+/-4 岁）和 46 岁（+/-10 岁）。随着年龄的增长，所有区域的外缘都变得更宽，并且变得更密集，其中特定区域似乎融合在较老的老花镜片中。虽然晶状体胎儿核透明度随着年龄的增长而降低，但它不具有不连续区域；相反，对称的无定形区域出现在前核和后核的中央。正视个体在指定的晶状体生长时期出现特定的不连续区域，与连续更复杂的晶状体缝合线的产生同步，强烈表明晶状体缝合线和不连续区域之间存在因果关系。
Statistical analysis of Scheimpflug images from the crystalline lenses of 100 emmetropic human subjects ranging in age from 18 to 70 yr confirms that specific zones of discontinuity are a function of lens development and growth. At and beyond the age of 40 yr, as many as four sharply demarcated and complementary zones are seen within the anterior and posterior lens cortex. The locations of the inner edges of the anterior cortical zones of discontinuity were characterized relative to the central sulcus of the lens. Consecutively from the central sulcus, the distances were 1.094, 1.415, 1.695, and 1.994 (+/-0.11 mm). Since nuclear thickness in the adult lens is age-independent and the rate of cortical growth has been characterized, the location of the inner margins of the zones are indicative of the age at which they originated; these ages were 4 (+/-1 yr), 9 (+/-2 yr), 19 (+/-4 yr), and 46 (+/-10 yr). All of the zones become broader along the outer margin and more dense upon aging, with specific zones appearing to merge in older presbyopic lenses. While lens fetal nuclear transparency decreases with age, it does not feature zones of discontinuity; instead, symmetrically amorphous regions appear centrally in the anterior and posterior nucleus. This demonstration of the onset of specific zones of discontinuity in emmetropic individuals, at defined periods of lens growth that are synchronous the production of successively more complex lens sutures, strongly suggests a causal relationship between lens sutures and the zones of discontinuity.