Obstetric outcome of 6346 pregnancies with infants affected by congenital heart defects
Obstetric outcome of 6346 pregnancies with infants affected by congenital heart defects
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DOI：
10.1016/j.ejogrb.2005.07.006
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发表时间：
2006-04-01
影响因子：
2.6
通讯作者：
Källén, BAJ
中科院分区：
文献类型：
--
作者：
Cedergren, MI;Källén, BAJ
目的：评价妊娠合并先天性心脏病是否与不良产科和围产期结局相关。研究设计：在瑞典进行的一项前瞻性人群队列研究对1992-2001年6346例单胎妊娠合并先天性心脏病患儿进行统计分析，并与同期分娩的所有产妇进行比较。心血管缺陷的患病率为每1000名新生儿9.1例。其中，6346名婴儿（71%）的母亲在怀孕早期有母亲吸烟习惯和母亲身高和体重的信息，这些信息可以计算BMI。排除了所有已知染色体异常和/或母体既存糖尿病的病例。84%（n = 5338）有孤立的心血管缺陷。重型占21.7%（n = 1378）。与所有分娩的妇女相比，患有先天性心脏病的婴儿的妊娠组发生以下结局的风险增加（调整OR（95%CI））：先兆子痫（1.21（1.06-1.37）），剖宫产（1.91（1.79-2.03）），分娩（1.21（1.10-1.34）），早产（2.58（2.39-2.79）），小于胎龄儿（1.96（1.77-2.16）），胎粪吸入（1.51（1.28-1.77））和胎儿窘迫（1.38（1.17-1.63））。结论：妊娠合并先天性心脏病的婴儿与几种产科和新生儿并发症有关。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Objective: To evaluate whether pregnancies with infants affected by congenital heart defects are associated with adverse obstetric and perinatal outcome.Study design: In a prospective population-based cohort study from Sweden (1992-2001), 6346 singleton pregnancies with infants affected by congenital heart defects were, after suitable adjustments, compared to all delivered women.Results: The prevalence of cardiovascular defects was 9.1 per 1000 births. Among them, mothers of 6346 infants (71%) had information on maternal smoking habits and maternal height and weight in early pregnancy that enabled the calculation of BMI. All cases with known chromosomal abnormalities and/or maternal pre-existing diabetes were excluded. Eighty-four percent (n = 5338) had an isolated cardiovascular defect. Severe types occurred in 21.7% (n = 1378). In the group of pregnancies with infants affected by congenital heart defects as compared to all delivered women, there was an increased risk of the following outcomes (adjusted OR (95%Cl)): pre-eclampsia (1.21 (1.06-1.37)), cesarean section (1.91 (1.79-2.03)), instrurnental delivery (1.21 (1.10-1.34)), pre-term delivery (2.58 (2.39-2.79)), small-for gestational age (1.96 (1.77-2.16)), meconium aspiration (1.51 (1.28-1.77)), and fetal distress (1.38 (1.17-1.63)).Conclusions: Pregnancies with infants affected by congenital heart defects are associated with several obstetric and neonatal complications. (c) 2005 Elsevier Ireland Ltd. All rights reserved.