Elevated body mass index in modified natural cycle frozen euploid embryo transfers is not associated with live birth rate.
Elevated body mass index in modified natural cycle frozen euploid embryo transfers is not associated with live birth rate.
复制标题
改良自然周期冷冻整倍体胚胎移植中体重指数升高与活产率无关。
DOI：
10.1007/s10815-023-02787-y
复制
发表时间：
2023
影响因子：
3.1
通讯作者：
Bavan,Brindha
中科院分区：
文献类型：
--
作者：
Beshar,Isabel;Milki,AminA;Gardner,RebeccaM;Zhang,WendyY;Johal,JasmynK;Bavan,Brindha
PurposeTo assess the impact of elevated BMI on the success of modified natural cycle frozen embryo transplants（mNC-FET）of eu ploid embryos.MethodsThis retrospective cohort study at a single academic institution reviewed mNC-FET involving single eu ploid blastocyte from 2016 to 2020.比较组按孕前BMI（kg/m2）分类：正常体重（18.5-24.9）、超重（25-29.9）或肥胖（≥ 30）。体重过轻的BMI（< 18.5）被排除在分析之外。主要结局是活产率（LBR），次要结局是临床妊娠率（CPR），定义为超声显示胎儿心脏活动。结果425例患者共完成mNC-FET治疗562个周期。总的来说，在正常体重患者中进行了316次转移，在超重患者中进行了165次转移，在肥胖患者中进行了81次转移。在所有BMI类别中，LBR没有统计学显著差异（55.4%正常体重，61.2%超重和64.2%肥胖）。次要结局CPR在所有类别中也没有差异（分别为58.5%，65.5%和66.7%）。这是证实了在GEE分析调整confounders.ConclusionWhile体重增加通常被牵连在不良妊娠结局，BMI的影响mNC-FET的成功仍然存在争议。在mNC-FET周期中使用整倍体胚胎的单个机构的五年数据中，BMI升高与LBR或CPR降低无关。
PurposeTo assess the impact of elevated BMI on the success of modified natural cycle frozen embryo transfers (mNC-FET) of euploid embryos.MethodsThis retrospective cohort study at a single academic institution reviewed mNC-FET involving single euploid blastocysts from 2016 to 2020. Comparison groups were divided by pre-pregnancy BMI (kg/m2) category: normal weight (18.5–24.9), overweight (25–29.9) or obese (≥ 30). Underweight BMI (< 18.5) was excluded from the analysis. The primary outcome was live birth rate (LBR) and secondary outcome was clinical pregnancy rate (CPR), defined as presence of fetal cardiac activity on ultrasound. Absolute standardized differences (ASD) were calculated to compare descriptive variables and p-values and multivariable logistic regressions with generalized estimating equations (GEE) were used to compare pregnancy outcomes.Results562 mNC-FET cycles were completed in 425 patients over the study period. Overall, there were 316 transfers performed in normal weight patients, 165 in overweight patients, and 81 in obese weight patients. There was no statistically significant difference in LBR across all BMI categories (55.4% normal weight, 61.2% overweight, and 64.2% obese). There was also no difference for the secondary outcome, CPR, across all categories (58.5%, 65.5%, and 66.7%, respectively). This was confirmed in GEE analysis when adjusting for confounders.ConclusionWhile increased weight has commonly been implicated in poor pregnancy outcomes, the effect of BMI on the success of mNC-FET remains debated. Across five years of data from a single institution using euploid embryos in mNC-FET cycles, elevated BMI was not associated with reduced LBR or CPR.