Cerebral ischemia in 5-lipoxygenase knockout mice
Cerebral ischemia in 5-lipoxygenase knockout mice
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DOI：
10.1016/j.brainres.2004.01.018
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发表时间：
2004-04-09
期刊：
影响因子：
2.9
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Kitagawa, K;Matsumoto, M;Hori, M
脑缺血诱导脑内5-脂氧合酶移位和白三烯产生。本研究利用5-脂氧合酶基因敲除小鼠，探讨5-脂氧合酶在脑缺血中的病理意义。两种类型的小鼠之间的永久性和短暂性缺血60分钟后的梗死面积没有观察到显着差异。目前的研究并不支持白三烯的产生参与局灶性脑缺血的梗死扩展的观点。(C)2004 Elsevier B. V.保留所有权利。
Cerebral ischemia induces 5-lipoxygenase translocation and leukotriene production in the brain. We tried to clarify the pathological significance of 5-lipoxygenase on cerebral ischemia using 5-lipoxygenase knockout mice. No significant difference was observed in the infarct size following permanent and transient ischemia for 60 min between both types of mice. The present study did not support the idea that leukotriene production is involved in infarct expansion in focal cerebral ischemia. (C) 2004 Elsevier B.V. All rights reserved.