Sensitivity and specificity of transtympanic electrocochleography in Meniere's disease
Sensitivity and specificity of transtympanic electrocochleography in Meniere's disease
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DOI：
10.1080/00016489850154838
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发表时间：
1998-03-01
影响因子：
1.4
通讯作者：
Sass, K
中科院分区：
文献类型：
--
作者：
Sass, K
对61例（61耳）临床诊断为梅尼埃病的患者和15例（21耳）其他原因所致的耳蜗性听力损失患者进行了经鼓室耳蜗电图（TT ECoG）检查，以评价TT ECoG对不同耳蜗疾病的区分能力。评价了短声诱发的总和电位/动作电位（SP/AP）比值以及1和2 kHz爆发诱发的SP振幅。根据13名听力正常受试者（15只耳朵）的TT ECoG结果，确定每个变量的上限，高于该上限的值被认为是病理性的，即指示内淋巴积水。结果表明，SP！AP诊断率为62%，特异性为95%。当评估TT ECoG参数与Logistic回归的组合，SP/AP比值和1 kHz爆发诱发的SP振幅被证明是提高TT ECoG的辨别能力显着。包括thr 1 kHz爆发诱发的SP振幅增加敏感性为82%，而不改变特异性。纳入2kHz脉冲群对灵敏度或特异性没有影响。
Transtympanic electrocochleography (TT ECoG) was conducted in 61 patients (61 ears) with the clinical diagnosis of Meniere's disease and 15 patients (21 ears) with cochlear hearing loss of other aetiologies to assess the ability of the method to separate different cochlear disorders. The click-evoked summation potential/action potential (SP/AP) ratio and the 1 and 2 kHz burst-evoked SP amplitudes were evaluated. Based on the TT ECoG results from 13 normal hearing subjects (15 ears) the upper limit of each variable was determined, above which a value was considered pathological, i.e. indicative of endolymphatic hydrops. The results showed that the sensitivity of the SP!AP ratio was 62% and specificity 95%. When evaluating the combinations of TT ECoG parameters with logistic regression, SP/AP ratio and 1 kHz burst-evoked SP amplitude were shown to increase the discriminating ability of TT ECoG significantly. Inclusion of thr 1 kHz burst-evoked SP amplitudes increased sensitivity to 82%, without changing specificity. Inclusion of the 2, kHz burst had no effect on sensitivity or specificity.