Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.
Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen.
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DOI：
10.3390/cells11010055
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发表时间：
2021-12-24
期刊：
影响因子：
6
通讯作者：
Nolte MA
中科院分区：
文献类型：
--
作者：
Goedhart M;Slot E;Pascutti MF;Geerman S;Rademakers T;Nota B;Huveneers S;Buul JDV;MacNamara KC;Voermans C;Nolte MA
除了控制造血功能外，骨髓 (BM) 还可以作为次级淋巴器官，因为它可以通过常驻树突细胞 (DC) 诱导幼稚 T 细胞启动。在分析小鼠 BM 中的 DC 时，我们发现它们位于血窦周围，可以（交叉）呈递抗原，在静脉注射 LPS 后被激活，并且大部分属于与 Th2/Th17 免疫相关的 cDC2 亚型。基因表达谱显示，BM 驻留 DC 富含多种 c 型凝集素，包括 Dectin-1，它可以结合真菌和酵母表达的 β-葡聚糖。事实上，BM 中的 DC 在吞噬酵母来源的酵母聚糖颗粒和曲霉分生孢子方面比脾脏中的 DC 更有效，而脾脏中的 DC 高度依赖于 Dectin-1。人骨髓中的 DC 还可以吞噬酵母聚糖，这依赖于 β1-整合素。此外，酵母聚糖刺激的BM驻留DC增强了造血干细胞和祖细胞向中性粒细胞的分化，同时也促进了这些祖细胞的维持。我们的研究结果表明 BM DC 作为感染和造血之间的翻译者发挥着重要作用，特别是在抗真菌免疫方面。从临床角度来看，BM 驻留 DC 促进中性粒细胞形成的能力是相关的，并有助于我们了解 BM 损伤后真菌感染的易感性增加。
Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing DCs in murine BM, we uncovered that they are localized around sinusoids, can (cross)-present antigens, become activated upon intravenous LPS-injection, and for the most part belong to the cDC2 subtype which is associated with Th2/Th17 immunity. Gene-expression profiling revealed that BM-resident DCs are enriched for several c-type lectins, including Dectin-1, which can bind beta-glucans expressed on fungi and yeast. Indeed, DCs in BM were much more efficient in phagocytosis of both yeast-derived zymosan-particles and Aspergillus conidiae than their splenic counterparts, which was highly dependent on Dectin-1. DCs in human BM could also phagocytose zymosan, which was dependent on β1-integrins. Moreover, zymosan-stimulated BM-resident DCs enhanced the differentiation of hematopoietic stem and progenitor cells towards neutrophils, while also boosting the maintenance of these progenitors. Our findings signify an important role for BM DCs as translators between infection and hematopoiesis, particularly in anti-fungal immunity. The ability of BM-resident DCs to boost neutrophil formation is relevant from a clinical perspective and contributes to our understanding of the increased susceptibility for fungal infections following BM damage.
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常规树突状细胞在调节中性粒细胞骨髓释放和存活中的核心作用。
DOI：
10.4049/jimmunol.1300237
发表时间：
2014-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jiao J;Dragomir AC;Kocabayoglu P;Rahman AH;Chow A;Hashimoto D;Leboeuf M;Kraus T;Moran T;Carrasco-Avino G;Friedman SL;Merad M;Aloman C
通讯作者：
Aloman C
DOI：
10.1038/nri3062
发表时间：
2011-09-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.5
作者：
Mitroulis I;Ruppova K;Wang B;Chen LS;Grzybek M;Grinenko T;Eugster A;Troullinaki M;Palladini A;Kourtzelis I;Chatzigeorgiou A;Schlitzer A;Beyer M;Joosten LAB;Isermann B;Lesche M;Petzold A;Simons K;Henry I;Dahl A;Schultze JL;Wielockx B;Zamboni N;Mirtschink P;Coskun Ü;Hajishengallis G;Netea MG;Chavakis T
通讯作者：
Chavakis T
影响因子：
3.1
作者：
Della Porta, M;Rigolin, GM;Castoldi, G
通讯作者：
Castoldi, G
影响因子：
20.3
作者：
de Bruin, Alexander M.;Libregts, Sten F.;Nolte, Martijn A.
通讯作者：
Nolte, Martijn A.