Advanced stage transitional cell carcinoma of the ovary
Advanced stage transitional cell carcinoma of the ovary
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DOI：
10.1016/s0046-8177(96)90335-4
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发表时间：
1996-12-01
期刊：
影响因子：
3.3
通讯作者：
Merino, MJ
中科院分区：
文献类型：
--
作者：
Hollingsworth, HC;Steinberg, SM;Merino, MJ
原发性卵巢移行细胞癌（TCC）最近被认为是上皮癌的一个独立亚型。已经提出，识别这种肿瘤在临床上是重要的，因为对化疗的有利反应和改善的患者存活率。作者回顾了58例晚期（III期和IV期）卵巢癌患者的组织学和临床病理结果，以确定TCC的频率并确认良好的预后。在这些病例中，15例（26%）被重新分类为TCC; 13例主要为TCC，2例为混合型，约50%的肿瘤为TCC。TCC患者的年龄范围为44至70岁（平均57岁）。其中10名患者为III期疾病，5名为IV期。单侧2例，双侧11例（2例不详）。肿瘤大小在3和23 cm之间变化。在III期患者中，5名患者进行了最佳减容，5名患者有残留病变。所有患者均接受相同类型的化疗。中位总生存期为28个月。TCC患者的临床结局与浆液性癌患者相比无显著差异。这些数据表明，TCC并不赋予一个良好的预后或更好的化疗反应率。
Primary transitional cell carcinoma (TCC) of the ovary has been recently recognized as a separate subtype of epithelial cancer. It has been proposed that recognition of such tumors is important on clinical grounds because of a favorable response to chemotherapy and an improved patient survival. The authors reviewed the histological and clinicopathologic findings of 58 patients with advanced stage (stages III and IV) ovarian cancer with a view to determining the frequency of TCC and confirming the favorable prognosis. Of these cases, 15 (26%) were reclassified as TCC; 13 were predominantly TCC, and 2 had a mixed pattern with approximately 50% of the tumor being TCC. TCC patients ranged in age from 44 to 70 years of age (mean, 57). Ten of the patients had stage III disease, and five were stage IV. The tumor was unilateral in 2 cases and bilateral in 11 (2 unknown). Tumor size varied between 3 and 23 cm. Of the stage III patients, five were optimally debulked, and five had residual disease. All patients received the same type of chemotherapy. The median overall survival was 28 months. There was no significant difference in the clinical outcome of patients with TCC compared with that of patients with serous carcinomas. These data suggest that TCC does not confer a favorable prognosis or better response rate to chemotherapy.