Smart Nanofibers with a Photoresponsive Surface for Controlled Release
Smart Nanofibers with a Photoresponsive Surface for Controlled Release
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DOI：
10.1021/am900526u
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发表时间：
2009-11-01
影响因子：
9.5
通讯作者：
Kang, En-Tang
中科院分区：
文献类型：
--
作者：
Fu, Guo-Dong;Xu, Li-Qun;Kang, En-Tang
基于光响应性和交联型纳米纤维表面的主客体相互作用，建立了一种新型的α-环糊精-5-氟尿酸(α-CD-5FU)前药的光控“开-关”释放体系。通过可控自由基聚合制备的嵌段共聚物电纺得到具有刺激响应表面的纳米纤维，然后通过“点击化学”进行表面修饰，并通过主-客体相互作用负载前药。
A novel phocontrolled "ON-OFF" release system for the alpha-cyclodextrin-5-fluorouracial (alpha-CD-5FU) prodrug, based on host-guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated. The nanofibers with a stimuli- responsive surface were electrospun from the block copolymer prepared via controlled radical polymerization, followed by surface modification via "Click Chemistry", and loading of the prodrug via host-guest interaction.