Stress and female reproductive function: A study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population
Stress and female reproductive function: A study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population
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压力和女性生殖功能：对玛雅农村人口皮质醇、促性腺激素和性腺类固醇日常变化的研究
DOI：
10.1002/ajhb.20057
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发表时间：
2004
影响因子：
2.9
通讯作者：
B. England
中科院分区：
文献类型：
--
作者：
P. Nepomnaschy;K. Welch;D. McConnell;B. Strassmann;B. England
我们在这里报告的压力和妇女的生殖在危地马拉农村的一个小Kaqchikel玛雅社区的纵向研究。目前对压力对女性生殖轴影响的认识主要来自对个体压力源的临床研究。然而，人们对“真实的生活”压力的累积效应知之甚少。皮质醇响应于各种各样的个体应激源而增加（Tilbrook等人，2002年）。在这篇文章中，我们评估妇女的尿皮质醇和生殖激素：雌酮结合物（E1 C），孕二醇葡糖苷酸（PdG），促黄体生成素（LH）和卵泡刺激素（FSH）的每日波动之间的关联。为了评估皮质醇水平的每日变化与生殖激素谱变化之间的关联，我们使用了基于多项式回归的随机系数模型。样本包括24名参与者在为期一年的前瞻性研究中提供的92个月经周期。在卵泡期，尿皮质醇水平的增加与促性腺激素和促性腺激素水平的显著增加相关。此外，在排卵后第4天至第10天的时间窗内，皮质醇水平升高与睾丸素水平显著降低相关。这些结果是重要的，因为促性腺激素的不合时宜的增加和低黄体中期孕酮水平先前已被报道会影响排卵和黄体化过程并降低成功着床的机会（Ferin，1999; Baird等人，1999年）。未来的研究应该考虑压力可能影响生育能力和着床，而不一定导致闭经或月经过少的可能性。Am. J. 16：523-532，2004.© 2004 Wiley利斯公司
We report here on a longitudinal study of stress and women's reproduction in a small Kaqchikel Mayan community in rural Guatemala. Current understanding of the effects of stress on the reproductive axis in women is mostly derived from clinical studies of individual stressors. Little is known, however, about the cumulative effects of “real life” stress. Cortisol increases in response to a broad variety of individual stressors (Tilbrook et al., 2002). In this article, we evaluate the association between daily fluctuations in women's urinary cortisol and reproductive hormones: estrone conjugates (E1C), pregnandiol glucuronide (PdG), luteinizing hormone (LH), and follicle stimulating hormone (FSH). To assess the association between daily changes in cortisol levels and changes in the profiles of the reproductive hormones, we used a random coefficients model based on polynomial regression. The sample includes 92 menstrual cycles provided by 24 participants over a year‐long prospective study. Increases in urinary cortisol levels were associated with significant increases in gonadotrophin and progestin levels during the follicular phase. Also, in a time window between days 4 and 10 after ovulation, increased cortisol levels were associated with significantly lower progestin levels. These results are significant because untimely increases in gonadotrophins and low midluteal progesterone levels have previously been reported to impinge on the ovulatory and luteinization processes and to reduce the chances of successful implantation (Ferin, 1999; Baird et al., 1999). Future research should consider the possibility that stress may affect fecundability and implantation without necessarily causing amenorrhoea or oligomenorrhoea. Am. J. Hum. Biol. 16:523–532, 2004. © 2004 Wiley‐Liss, Inc.
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使用尿孕二醇-3-葡萄糖苷酸比率算法识别无排卵和短暂黄体功能。
影响因子：
10.4
作者：
Kassam,A;Overstreet,JW;Snow-Harter,C;DeSouza,MJ;Gold,EB;Lasley,BL
通讯作者：
Lasley,BL
DOI：
10.1210/jcem.83.12.5334
发表时间：
1998-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
M. J. Souza;B. E. Miller;A. Loucks;A. Luciano;L. Pescatello;C. Campbell;B. Lasley
通讯作者：
M. J. Souza;B. E. Miller;A. Loucks;A. Luciano;L. Pescatello;C. Campbell;B. Lasley
影响因子：
5.8
作者：
LOUCKS, AB;MORTOLA, JF;YEN, SSC
通讯作者：
YEN, SSC
剧烈运动训练期间食蟹猴生殖激素和月经周期的纵向变化：突然转变为运动引起的闭经。
影响因子：
4.8
作者：
Williams,NI;Caston-Balderrama,AL;Helmreich,DL;Parfitt,DB;Nosbisch,C;Cameron,JL
通讯作者：
Cameron,JL
影响因子：
4.8
作者：
FENG, YJ;SHALTS, E;FERIN, M
通讯作者：
FERIN, M