Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB1 cannabinoid receptors
Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB1 cannabinoid receptors
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DOI：
10.1177/0269881110370503
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发表时间：
2011-12-01
影响因子：
4.1
通讯作者：
Viveros, M-P
中科院分区：
文献类型：
--
作者：
Mateos, B.;Borcel, E.;Viveros, M-P
我们分析了雄性和雌性大鼠在青春期（出生后28-43天）暴露于尼古丁（NIC， 1.4 mg/kg/天）和/或大麻素激动剂CP 55,940 （CP， 0.4 mg/kg/天）对成年期测量的以下参数的长期影响：(1)在物体定位任务（OL）和新物体测试（NOT）中评估的记忆能力；(2)高架+迷宫的类焦虑行为；(3)扣带皮层和海马中的尼古丁和CBI大麻素受体。在OL中，所有药物治疗均能显著降低女性DI，而对男性DI无显著影响。在NOT中，nici治疗的雌性表现出显著降低的DI，而大麻素激动剂的作用（降低DI）仅在雄性中显著。焦虑相关的行为没有被任何药物改变。尼古丁和大麻素治疗均诱导雄性大鼠CBI受体活性（cp刺激的GTP γ S结合）持续增加，尼古丁治疗还诱导雌性大鼠前额叶皮层尼古丁受体密度下降。结果显示，药物对性别的有害影响以及CBI和尼古丁受体的长期变化。
We have analysed the long-term effects of adolescent (postnatal day 28-43) exposure of male and female rats to nicotine (NIC, 1.4 mg/kg/day) and/or the cannabinoid agonist CP 55,940 (CP, 0.4 mg/kg/day) on the following parameters measured in the adulthood: (1) the memory ability evaluated in the object location task (OL) and in the novel object test (NOT); (2) the anxiety-like behaviour in the elevated plus maze; and (3) nicotinic and CBI cannabinoid receptors in cingulated cortex and hippocampus. In the OL, all pharmacological treatments induced significant decreases in the DI of females, whereas no significant effects were found among males. In the NOT, NIC-treated females showed a significantly reduced DI, whereas the effect of the cannabinoid agonist (a decrease in the DI) was only significant in males. The anxiety-related behaviour was not changed by any drug. Both, nicotine and cannabinoid treatments induced a long-lasting increase in CBI receptor activity (CP-stimulated GTP gamma S binding) in male rats, and the nicotine treatment also induced a decrease in nicotinic receptor density in the prefrontal cortex of females. The results show gender-dependent harmful effects of both drugs and long-lasting changes in CBI and nicotinic receptors.