Cell therapy with bone marrow cells for myocardial regeneration.
Cell therapy with bone marrow cells for myocardial regeneration.
复制标题
使用骨髓细胞进行心肌再生的细胞疗法。
DOI：
10.1089/ars.2009.2486
复制
发表时间：
2009
影响因子：
6.6
通讯作者：
Yoon,Young-Sup
中科院分区：
文献类型：
--
作者：
Kim,Hyongbum;Kim,Sung-Whan;Nam,Douglas;Kim,Sinae;Yoon,Young-Sup
细胞疗法对于自我更新能力有限的受损心脏具有巨大潜力。骨髓 (BM) 细胞对于细胞治疗很有吸引力，因为它们含有不同的干细胞和祖细胞群，可以产生各种细胞类型，包括心肌细胞、内皮细胞和平滑肌细胞。研究表明骨髓细胞在治疗心肌梗塞方面是安全有效的。由宿主细胞和移植细胞介导的可能的治疗机制包括心肌生成、新血管形成和不良重塑的减弱。在这篇综述中，综述了骨髓中的不同干细胞和祖细胞及其在细胞治疗中的应用，并讨论了其治疗机制的证据。抗氧化。氧化还原信号.11, 1897–1911。
Cell therapy has tremendous potential for the damaged heart, which has limited self-renewing capability. Bone marrow (BM) cells are attractive for cell therapy, as they contain diverse stem and progenitor cell populations that can give rise to various cell types, including cardiomyocytes, endothelial cells, and smooth muscle cells. Studies have shown BM cells to be safe and efficacious in the treatment of myocardial infarction. Possible therapeutic mechanisms mediated by both host and transplanted cells include cardiomyogenesis, neovascularization, and attenuation of adverse remodeling. In this review, different stem and progenitor cells in the bone marrow and their application in cell therapy are reviewed, and evidence for their therapeutic mechanisms is discussed.Antioxid. Redox Signal.11, 1897–1911.