Neurotoxic or Neuroprotective? Current Controversies in SCI-Induced Autoimmunity.
Neurotoxic or Neuroprotective? Current Controversies in SCI-Induced Autoimmunity.
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DOI：
10.1007/s40141-013-0021-2
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发表时间：
2013-09
影响因子：
1.1
通讯作者：
Morse LR
中科院分区：
文献类型：
--
作者：
Saltzman JW;Battaglino R;Stott H;Morse LR
关于创伤性脊髓损伤（SCI）后观察到的自身免疫反应存在争议。目前尚不清楚这是否代表免疫系统防止进一步组织损伤的保护性反应、免疫系统对损伤释放的中枢神经系统抗原的病理反应，或者两者的组合。实验证据表明，SCI 后 B 细胞会产生自身抗体，并且自身反应性抗体的存在与组织损伤有关。相反，其他研究表明损伤部位的 T 细胞活性可促进组织再生。使用暴露于中枢神经系统（CNS）抗原的树突状细胞进行疫苗接种可显着改善脊髓损伤大鼠运动功能的恢复。需要进一步研究来确定 SCI 后 B 细胞和 T 细胞反应的性质，并确定临床研究中树突状细胞疫苗接种疗法的功效。这些信息对于开发抑制或促进神经创伤后免疫反应以改善神经系统结果的疗法至关重要。
Controversy exists regarding the autoimmune response that has been observed following traumatic spinal cord injury (SCI). It is not clear if this represents a protective response by the immune system to prevent further tissue damage, a pathological reaction of the immune system to central nervous system antigens released by the injury, or a combination of both. Experimental evidence indicates that B cells produce auto-antibodies following SCI and that the presence of self-reactive antibodies is associated with tissue damage. Conversely, other studies suggest T cell activity at the site of the injury promotes tissue regeneration. Vaccination with dendritic cells exposed to central nervous system (CNS) antigens dramatically improves recovery of motor function in spinal cord injured rats. Further research is required to determine the nature of post-SCI B cell and T cell responses and to establish efficacy of dendritic cell vaccination therapy in clinical studies. This information is critical for the development of therapies to either suppress or promote immune responses following neurotrauma to improve neurological outcomes.