MAOA-L carriers are better at making optimal financial decisions under risk
MAOA-L carriers are better at making optimal financial decisions under risk
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DOI：
10.1098/rspb.2010.2304
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发表时间：
2011-07-07
影响因子：
4.7
通讯作者：
Rangel, Antonio
中科院分区：
文献类型：
--
作者：
Frydman, Cary;Camerer, Colin;Rangel, Antonio
基因可以通过至少两种不同的神经计算机制影响对风险的行为：它们可能影响分配给不同风险选项的价值，或者它们可能影响大脑根据选项的价值在选项之间做出判断的方式。我们结合神经经济学和行为遗传学的方法，研究编码单胺氧化酶-A(MAOA)、5-羟色胺转运体(5-HTT)和多巴胺D4受体(DRD4)的基因对这两种计算的影响。与以前的文献一致，我们发现MAOA-L基因的携带者更有可能承担经济风险。我们的计算选择模型植根于既定的决策理论，该模型表明，MAOA-L运营商之所以表现出这种行为，是因为他们能够在风险下做出更好的财务决策，而不是因为他们更冲动。相反，我们没有发现5-HTT和DRD4基因的多态在行为或计算上的差异。
Genes can affect behaviour towards risks through at least two distinct neurocomputational mechanisms: they may affect the value assigned to different risky options, or they may affect the way in which the brain adjudicates between options based on their value. We combined methods from neuroeconomics and behavioural genetics to investigate the impact that the genes encoding for monoamine oxidase-A (MAOA), the serotonin transporter (5-HTT) and the dopamine D4 receptor (DRD4) have on these two computations. Consistent with previous literature, we found that carriers of the MAOA-L polymorphism were more likely to take financial risks. Our computational choice model, rooted in established decision theory, showed that MAOA-L carriers exhibited such behaviour because they are able to make better financial decisions under risk, and not because they are more impulsive. In contrast, we found no behavioural or computational differences among the 5-HTT and DRD4 polymorphisms.