Predictive, personalized, preventive, participatory (P4) cancer medicine
Predictive, personalized, preventive, participatory (P4) cancer medicine
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DOI：
10.1038/nrclinonc.2010.227
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发表时间：
2011-03-01
影响因子：
78.8
通讯作者：
Friend, Stephen H.
中科院分区：
文献类型：
--
作者：
Hood, Leroy;Friend, Stephen H.
在未来的十年里，医学将从一个被动的学科转变为一个主动的学科，一个具有预测性、个性化、预防性和参与性的学科。P4医学将受到疾病系统方法、新兴技术和分析工具的推动。实现P4医学将面临两大挑战-技术和社会障碍-而社会障碍将证明是最具挑战性的。我们如何使患者、医生和卫生保健界的成员与P4医学的巨大机遇保持一致？在某种程度上，这将通过建立新型的战略伙伴关系来实现--在患者、大型临床中心、临床中心联盟和患者倡导团体之间。对于一些临床试验来说，需要招募大量的患者，而应对这一挑战的一个强有力的方法是通过将大型临床中心与患者倡导团体聚集在一起来招募患者。
Medicine will move from a reactive to a proactive discipline over the next decade-a discipline that is predictive, personalized, preventive and participatory (P4). P4 medicine will be fueled by systems approaches to disease, emerging technologies and analytical tools. There will be two major challenges to achieving P4 medicine-technical and societal barriers-and the societal barriers will prove the most challenging. How do we bring patients, physicians and members of the health-care community into alignment with the enormous opportunities of P4 medicine? In part, this will be done by the creation of new types of strategic partnerships-between patients, large clinical centers, consortia of clinical centers and patient-advocate groups. For some clinical trials it will necessary to recruit very large numbers of patients-and one powerful approach to this challenge is the crowd-sourced recruitment of patients by bringing large clinical centers together with patient-advocate groups.