Sexual experience of male rats influences anxiety-like behavior and androgen levels
Sexual experience of male rats influences anxiety-like behavior and androgen levels
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DOI：
10.1016/j.physbeh.2007.04.018
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发表时间：
2007-10-22
影响因子：
2.9
通讯作者：
Frye, Cheryl A.
中科院分区：
文献类型：
--
作者：
Edinger, Kassandra L.;Frye, Cheryl A.
有大量文献表明，性经验可能会影响各种物种的雄激素分泌，反过来，雄激素也可能影响焦虑。我们假设性经验可能会改变焦虑行为和内源性雄激素的分泌。实验1：将有性经验的大鼠的焦虑行为与没有性经验的幼稚雄性大鼠的焦虑行为进行比较。有性经验的大鼠在开阔视野和高架十字迷宫中表现出较少的焦虑样行为，并表现出血浆和海马睾酮（T）水平升高。实验二：检查了最近的性经历对有性经历的雄性大鼠、有性反应但无经验的雄性大鼠和在测试前立即暴露于接受性雌性的无性反应、无经验的雄性大鼠的焦虑行为的影响。最近的性经验显着减少焦虑样行为在开放领域，高架十字迷宫，高架零迷宫任务，并倾向于减少焦虑样行为在光暗任务。最近的性经验的大鼠表现出增加血浆和海马T水平。实验三：为了检查最近性经历的影响，将具有性经历史的大鼠（在测试之前立即与刺激雌性进行性经历）的焦虑行为与具有性经历史的大鼠（在行为测试之前没有立即进行性经历）的焦虑行为进行比较。在试验前暴露于雌性的有经验大鼠在旷场、高架十字迷宫和明暗转换任务中表现出焦虑样行为减少，并表现出血浆和下丘脑T和3 α-二醇增加，海马T增加。因此，性经验与较低水平的焦虑样行为和较高水平的雄激素分泌有关。(c)2007爱思唯尔公司All rights reserved.
There is a wide body of literature to suggest that sexual experience may influence androgen secretion in various species, in turn, androgens may also influence anxiety. We hypothesized that sexual experience may alter anxiety behavior and secretion of endogenous androgens. Experiment 1: anxiety behavior of rats with a history of sexual experience was compared to that of sexually-inexperienced, naive male rats. Sexually-experienced rats showed less anxiety-like behavior in the open field and elevated plus maze, and exhibited increased plasma and hippocampal testosterone (T) levels. Experiment 2: the effects of recent sexual experience on anxiety behavior of sexually-experienced male rats, sexually-responsive but inexperienced male rats, and sexually-unresponsive, inexperienced male rats exposed to a receptive female immediately prior to testing was examined. Recent sexual experience significantly decreased anxiety-like behavior in the open field, elevated plus maze, and the elevated zero maze tasks, and tended to decrease anxiety-like behavior in the light-dark task. Rats with recent sexual experience exhibited increased plasma and hippocampal T levels. Experiment 3: to examine the effect of recent sexual experience, anxiety behavior of rats with a history of sexual experience that received sexual experience with a stimulus female immediately prior to testing was compared to that of rats with a history of sexual experience that did not receive sexual experience immediately prior to behavioral testing. Experienced rats that were exposed to a female prior to testing showed decreased anxiety-like behavior in the open field, elevated plus maze, and light-dark transition tasks, and showed increased plasma and hypothalamic, T and 3 alpha-diol, and increased hippocampal T. Thus, sexual experience is associated with lower levels of anxiety-like behavior and higher levels of androgen secretion. (c) 2007 Elsevier Inc. All rights reserved.