Poor Sleep and Altered Hypothalamic-Pituitary-Adrenocortical and Sympatho-Adrenal-Medullary System Activity in Children
Poor Sleep and Altered Hypothalamic-Pituitary-Adrenocortical and Sympatho-Adrenal-Medullary System Activity in Children
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DOI：
10.1210/jc.2009-0943
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发表时间：
2010-05-01
影响因子：
5.8
通讯作者：
Kajantie, Eero
中科院分区：
文献类型：
--
作者：
Raikkonen, Katri;Matthews, Karen A.;Kajantie, Eero
神经内分泌改变与健康有着众所周知的联系，这可能会让我们深入了解为什么睡眠不佳与健康状况不佳有关。然而，测试儿童睡眠和神经内分泌活动之间关系的研究很少。目的：本研究的目的是确定基于活动记录的睡眠模式是否与儿童下丘脑-垂体-肾上腺皮质轴和交感-肾上腺-髓质系统活动有关。设计和设置：我们在芬兰赫尔辛基的一个出生队列中进行了一项横断面研究。参与者：我们研究了282名8岁的儿童。主要结果测量：我们测量了昼夜唾液皮质醇和唾液皮质醇和α-淀粉酶（一种交感-肾上腺-髓质系统标记物）对特里尔儿童社会应激测试（TSST-C）的反应。结果：短（
Context: Neuroendocrine alterations, with well-known links with health, may offer insight into why poor sleep is associated with poor health. Yet, studies testing associations between sleep and neuroendocrine activity in children are scarce.Objective: The aim of this study was to determine whether actigraphy-based sleep pattern is associated with hypothalamic-pituitary-adrenocortical axis and sympatho-adrenal-medullary system activity in children.Design and Setting: We conducted a cross-sectional study in a birth cohort in Helsinki, Finland.Participants: We studied 282 8-yr-old children.Main Outcome Measures: We measured diurnal salivary cortisol and salivary cortisol and alpha-amylase (a sympatho-adrenal-medullary system marker) responses to the Trier Social Stress Test for Children (TSST-C).Results: Children with short (