Spatial Variation in Osteonal Bone Properties Relative to Tissue and Animal Age
Spatial Variation in Osteonal Bone Properties Relative to Tissue and Animal Age
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DOI：
10.1359/jbmr.090201
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发表时间：
2009-07-01
影响因子：
6.2
通讯作者：
Boskey, Adele L.
中科院分区：
文献类型：
--
作者：
Gourion-Arsiquaud, Samuel;Burket, Jayme C.;Boskey, Adele L.
骨细胞骨矿物质和基质的性质知之甚少，尽管这些性质对于了解与年龄和骨质疏松症等骨疾病相关的骨改变非常重要。在老化过程中，骨发生改变，损害其结构完整性，临床上表现为骨折发生率随年龄增加。基于傅立叶变换红外（FTIR）分析前狒狒0和32岁之间的年龄，一致的系统变化，骨特性作为组织年龄的函数内骨单位的报告。观察到的模式是独立的动物年龄和正相关的骨组织的弹性行为测量纳米压痕。只要组织年龄表示为整个骨单位半径的百分比，骨细胞分析可以用于表征疾病的变化，而不依赖于骨单位的大小。这些矿物质和基质分析可用于解释骨脆性。矿物质含量（矿物质-基质比）与动物年龄相关的老（间质）和新形成的骨组织，首次表明年龄相关的BMC变化可以解释的矿化过程本身的改变，而不仅仅是在重塑过程中的不平衡。骨矿研究杂志2009;24：1271-1281。在线发表于2009年2月9日; doi：10.1359/JBMR.090201
Little is known about osteonal bone mineral and matrix properties, although these properties are of major importance for the understanding of bone alterations related to age and bone diseases such as osteoporosis. During aging, bone undergoes modifications that compromise their structural integrity as shown clinically by the increase of fracture incidence with age. Based on Fourier transform infrared (FTIR) analysis front baboons between 0 and 32 yr of age, consistent systematic variations in bone properties as a function of tissue age are reported within osteons. The patterns observed were independent of animal age and positively correlated with bone tissue elastic behavior measured by nano-indentation. As long as tissue age is expressed as a percentage of the entire osteon radius, osteonal analyses can be used to characterize disease changes independent of the size of the osteon. These mineral and matrix analyses can be used to explain bone fragility. The mineral content (mineral-to-matrix ratio) was correlated with the animal age in both old (interstitial) and newly formed bone tissue, showing for the first time that age-related changes in BMC can be explain by an alteration in the mineralization process itself and not only by an imbalance in the remodeling process. J Bone Miner Res 2009;24:1271-1281. Published online on February 9, 2009; doi: 10.1359/JBMR.090201