ROS-sensitive calcipotriol nano-micelles prepared by methoxypolyethylene glycol (mPEG) - modified polymer for the treatment of psoriasis.
ROS-sensitive calcipotriol nano-micelles prepared by methoxypolyethylene glycol (mPEG) - modified polymer for the treatment of psoriasis.
复制标题
甲氧基聚乙二醇（mPEG）改性聚合物制备的ROS敏感卡泊三醇纳米胶束用于治疗银屑病
DOI：
10.1080/10717544.2022.2086944
复制
发表时间：
2022-12
期刊：
影响因子：
6
通讯作者：
Wang, Yuzhen
中科院分区：
文献类型：
--
作者：
Hua, Yulin;Chang, Tiantian;Jiang, Kun;Wang, Jinhong;Cui, Xiaodong;Cheng, Min;Yan, Fang;Song, Bo;Wang, Yuzhen
皮肤微环境中活性氧（ROS）产生过多引起的氧化应激是银屑病发病的主要机制之一。基于ROS响应性释放的纳米给药系统可以增强药物在靶位的释放。本研究以聚乙二醇（mPEG）为母体结构，通过硫化物结构修饰，合成了一种ROS敏感材料甲氧基聚乙二醇-硫醚-硫醇（mPEG-SS）。以卡泊三醇（mPEG-SS-CPT，PSC）为囊材，制备了mPEG-SS-CPT纳米胶束经皮给药系统。采用小动物成像系统研究PSC的ROS敏感性药物释放过程。研究表明，内源性活性氧主要影响PSC并释放药物。最后，通过动物实验探讨PSC对银屑病的治疗作用。最终，它改善了咪喹莫特诱导的银屑病样炎症。总体而言，PSC是一种有效的ROS敏感性透皮给药系统，有望为治疗银屑病提供新的策略。
Oxidative stress due to excessive reactive oxygen species (ROS) production in the skin microenvironment is one of the main mechanisms in psoriasis pathogenesis. A nano drug delivery system based on ROS-responsive release can enhance drug release at the target site. In this study, a ROS-sensitive material methoxypolyethylene glycol-thioether-thiol (mPEG-SS) was synthesized using mPEG as the parent structure with sulfide structural modification. An mPEG-SS-calcipotriol (mPEG-SS-CPT, PSC) nano-micelle percutaneous delivery system was prepared by encapsulating CPT. A small animal imaging system was used to study PSC’s the ROS-sensitive drug release process. It is shown that endogenous ROS mainly affects PSC and releases drugs. Finally, the therapeutic effect of PSC on psoriasis was explored by animal experiments. Ultimately, it ameliorates imiquimod-induced psoriasis-like inflammation. Overall, PSC is an effective ROS-sensitive transdermal drug delivery system that is expected to provide a new strategy for treating psoriasis.
登录
查看更多内容
影响因子：
10.8
作者：
Keum, Hyeongseop;Kim, Tae Woo;Jon, Sangyong
通讯作者：
Jon, Sangyong
影响因子：
11.4
作者：
Hu C;Wu Z;Huang Z;Hao X;Wang S;Deng J;Yin Y;Tan C
通讯作者：
Tan C
DOI：
10.1073/pnas.1405798111
发表时间：
2014-09-02
影响因子：
11.1
作者：
Khmaladze, Ia;Kelkka, Tiina;Holmdahl, Rikard
通讯作者：
Holmdahl, Rikard
影响因子：
5
作者：
Ali, Farrah;Khan, Bilal Azhar;Sultana, Sarwat
通讯作者：
Sultana, Sarwat
影响因子：
5.5
作者：
Niki, Etsuo
通讯作者：
Niki, Etsuo