PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort.
PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort.
复制标题
DOI：
10.1371/journal.pone.0078688
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Karpyak VM
中科院分区：
文献类型：
--
作者：
Preuss UW;Winham SJ;Biernacka JM;Geske JR;Bakalkin G;Koller G;Zill P;Soyka M;Karpyak VM
One of the proposed psychobiological pathways of craving attributes the desire for drinking in the context of tension, discomfort or unpleasant emotions, to “negative” (or “relief”) craving. The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping approach. The TaqMan® Genotyping Assay was used to genotype the rs2281285 variant in 417 German alcohol-dependent subjects. The presence of negative/relief craving was assessed by asking if participants ever ingested alcohol to avoid unwanted emotional or somatic discomfort. The minor allele of rs2281285 was associated with an increased risk of drinking to avoid/escape unwanted emotional or somatic events (OR = 2.29, 95% CI = 1.08–4.85, p = 0.0298). Despite the use of a different phenotyping approach to the measurement of negative craving, our results confirm the association between negative craving and PDYN rs2281285. Genetic markers of negative craving may help to identify subgroups of alcohol-dependent individuals vulnerable to relapse in the context of negative emotions or somatic discomfort, leading to the development of specifically tailored treatment strategies.
登录
查看更多内容
DOI：
10.1016/s0197-2456(03)00112-0
发表时间：
2004-02-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Rush, AJ;Fava, M;Niederehe, G
通讯作者：
Niederehe, G
影响因子：
4.7
作者：
Galeote, Lola;Maldonado, Rafael;Berrendero, Fernando
通讯作者：
Berrendero, Fernando
影响因子：
2.8
作者：
Heinz, A;Löber, S;Mann, K
通讯作者：
Mann, K
DOI：
10.1017/s1461145712001137
发表时间：
2013-06
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Karpyak VM;Winham SJ;Preuss UW;Zill P;Cunningham JM;Walker DL;Lewis KA;Geske JR;Colby CL;Abulseoud OA;Hall-Flavin DK;Loukianova LL;Schneekloth TD;Frye MA;Bazov I;Heit JA;Bakalkin G;Mrazek DA;Biernacka JM
通讯作者：
Biernacka JM
影响因子：
2.8
作者：
Ji, Y.;Biernacka, J. M.;Mrazek, D. A.
通讯作者：
Mrazek, D. A.