Retrospective Studyof 18F-FDG PET/CT in the Diagnosis of Inflammatory Breast Cancer: Preliminary Data
Retrospective Studyof 18F-FDG PET/CT in the Diagnosis of Inflammatory Breast Cancer: Preliminary Data
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DOI：
10.2967/jnumed.108.056010
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发表时间：
2009-02-01
影响因子：
9.3
通讯作者：
Yang, Wei-Tse
中科院分区：
文献类型：
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作者：
Carkaci, Selin;Macapinlac, Homer A.;Yang, Wei-Tse
我们的目的是回顾性评价F-18-FDG PET/CT在炎症性乳腺癌（IBC）初始分期中的作用。研究方法：机构审查委员会放弃知情同意并批准了本研究，该研究符合健康保险携带和责任法案。回顾性分析了1例平均年龄为50岁（范围，25-71岁）的新诊断的IBC女性病例，她们在诊断时接受了F-18-FDG PET/CT。所有PET/CT图像均由2名医生进行目视和半定量分析。记录原发乳腺、区域淋巴结（腋窝、胸大肌下、锁骨上、内乳）和结节区域的最大标准化摄取值。通过组织病理学分析（如可用）、同期或后续成像结果（对比增强CT、对比增强MRI、超声检查或PET/CT随访）或临床随访评估PET/CT图像解读的准确性。结果：所有患者均表现为单侧IBC。PET/CT显示所有患者的皮肤、40例（98%）受累乳房、37例（90%）同侧腋窝淋巴结和18例（44%）同侧胸大肌下淋巴结均存在高代谢摄取。20例患者（49%）在分期时发现有远处转移，其中7例（17%）在接受PET/CT之前不知道有转移。疾病部位包括骨、肝脏、对侧腋窝、肺、胸壁、骨盆以及胸大肌下、锁骨上、内乳、纵隔和腹部淋巴结。结论：PET/CT应该被认为是IBC的初始分期，因为该技术在这项初步的回顾性研究中提供了有关局部和远处疾病的有价值的信息。
Our objective was to retrospectively evaluate F-18-FDG PET/CT in the initial staging of inflammatory breast cancer (IBC). Methods: The institutional review board waived informed consent and approved this study, which was compliant with the Health insurance Portability and Accountability Act. The cases of 1 women with a mean age of 50 y (range, 25-71 y) and newly diagnosed IBC who underwent F-18-FDG PET/CT at diagnosis were retrospectively reviewed. All PET/CT images were analyzed visually and semiquantitatively by 2 physicians. The maximum standardized uptake value in the primary breast, regional nodes (axillary, subpectoral, supraclavicular, internal mammary), and extranodal regions was documented. The accuracy of PET/CT image interpretation was assessed by histopathologic analysis, if available; concurrent or subsequent imaging findings (contrast-enhanced CT, contrast-enhanced MRI, sonography, or PET/CT follow-up); or clinical follow-up. Results: All patients presented with unilateral IBC. PET/CT showed hypermetabolic uptake in the skin in all patients, in the affected breast in 40 (98%), in the ipsilateral axillary nodes in 37 (90%), and in the ipsilateral subpectoral nodes in 18 (44%). Twenty patients (49%) were found to have distant metastases at staging, 7 (17%) of whom were not known to have metastases before undergoing PET/CT. Disease sites included bone, liver, contralateral axilla, lung, chest wall, pelvis, and the subpectoral, supraclavicular, internal mammary, mediastinal, and abdominal nodes. Conclusion: PET/CT should be considered in the initial staging of IBC, as the technique provided valuable information on locoregional and distant disease in this preliminary retrospective study.