Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.
Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.
复制标题
大脑中的营养传感器指导果蝇中脑肠轴的作用。
DOI：
10.1016/j.neuron.2015.05.032
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发表时间：
2015-07-01
期刊：
影响因子：
16.2
通讯作者：
Suh GS
中科院分区：
文献类型：
--
作者：
Dus M;Lai JS;Gunapala KM;Min S;Tayler TD;Hergarden AC;Geraud E;Joseph CM;Suh GS
动物可以在不受味觉影响的情况下检测和消耗营养糖。然而，不依赖于味道的营养传感器的身份以及动物对糖的营养价值做出反应的机制尚不清楚。在这里，我们报告说，六个神经分泌细胞在果蝇脑中产生利尿激素44（Dh 44），哺乳动物促肾上腺皮质激素释放激素（CRH）的同系物，特别是激活营养糖。这些神经元的活性或Dh 44的表达被破坏的果蝇未能选择营养性糖。操纵Dh 44受体的功能也有类似的效果。值得注意的是，Dh 44受体-1神经元的人工激活导致长鼻延长和频繁的排泄。相反，Dh 44活性降低导致排泄减少。这些作用共同促进营养食物的摄取和消化。我们提出Dh 44系统通过正反馈回路指导营养性糖的检测和消耗。
Animals can detect and consume nutritive sugars without the influence of taste. However, the identity of the taste-independent nutrient sensor and the mechanism by which animals respond to the nutritional value of sugar are unclear. Here, we report that six neurosecretory cells in the Drosophila brain that produce Diuretic hormone 44 (Dh44), a homologue of the mammalian corticotropin-releasing hormone (CRH), were specifically activated by nutritive sugars. Flies in which the activity of these neurons or the expression of Dh44 was disrupted failed to select nutritive sugars. Manipulation of the function of Dh44 receptors had a similar effect. Notably, artificial activation of Dh44 receptor-1 neurons resulted in proboscis extensions, and frequent episodes of excretion. Conversely, reduced Dh44 activity led to decreased excretion. Together, these actions facilitate ingestion and digestion of nutritive foods. We propose that the Dh44 system directs the detection and consumption of nutritive sugars through a positive feedback loop.