Autonomic impairment in a transgenic mouse model of amyotrophic lateral sclerosis
Autonomic impairment in a transgenic mouse model of amyotrophic lateral sclerosis
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DOI：
10.1016/j.autneu.2010.09.002
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发表时间：
2011-01-20
影响因子：
2.7
通讯作者：
Drory, Vivian E.
中科院分区：
文献类型：
--
作者：
Kandinov, Boris;Korczyn, Amos D.;Drory, Vivian E.
肌萎缩性侧索硬化症（ALS）是一种以运动神经元进行性丧失为特征的神经退行性疾病，然而人们越来越认识到非运动表现也可能出现，包括自主神经系统功能障碍。为了更好地了解ALS中的自主神经参与，我们测量了携带SOD1 （G93A）突变的转基因（TG）小鼠和野生型（WT）对照小鼠的自主神经功能。除疾病晚期（19-20周龄）外，TG小鼠在休息和应激后的心率均高于WT小鼠。WT和TG小鼠静息时平均瞳孔直径相似；然而，甘油三酯小鼠在给药吗啡后蛔虫减少。TG小鼠和WT小鼠在静息、暴露于冷应激和注射吗啡（30 mg/kg）后的直肠温度没有差异，但在疾病晚期，TG小鼠在冷应激和注射吗啡后的直肠温度明显低于WT小鼠。结果提示自主神经系统损伤在这个ALS模型中，与人类的临床数据一致。(C) 2010 Elsevier B.V.版权所有
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss of motor neurons, however it is increasingly recognized that nonmotor manifestations may occur, including autonomic nervous system dysfunction. To better understand the autonomic involvement in ALS we measured autonomic functions in transgenic (TG) mice carrying an SOD1 (G93A) mutation and wild-type (WT) control mice. TG mice had a higher heart rate at rest and following stress than WT mice at all ages except for the advanced stages of the disease (19-20 weeks of age). The mean pupil diameter at rest was similar in WT and TG mice; however, TG mice had decreased mydriasis following administration of morphine. The rectal temperature did not differ between TG and WT mice at rest, during exposure to cold stress and following administration of morphine (30 mg/kg) except for the advanced stages of the disease in which TG mice had significantly lower temperatures than WT mice during cold stress and following morphine administration. The results suggest autonomic nervous system impairment in this ALS model, consistent with clinical data in humans. (C) 2010 Elsevier B.V. All rights reserved.