Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.
Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.
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DOI：
10.1016/j.bbcan.2015.08.003
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Batra SK
中科院分区：
文献类型：
--
作者：
Chugh S;Gnanapragassam VS;Jain M;Rachagani S;Ponnusamy MP;Batra SK
粘蛋白是上皮细胞上表达的大糖蛋白，可提供保护屏障，抵御毒素和病原微生物的严重侵害。这些糖蛋白主要分为分泌型和膜结合型；这两种形式都涉及病理生理功能，包括炎症和癌症。粘蛋白的高分子量归因于其大的多肽主链，该主链广泛地被调节粘蛋白功能的聚糖部分覆盖，因此在生理功能中发挥重要作用。恶性转化过程中糖基化机制的失调导致粘蛋白糖基化的改变。这篇综述描述了癌症中粘蛋白糖基化改变的功能意义和病理学意义。此外，这篇综述描述了导致癌症期间粘蛋白糖基化失调的各种因素，例如糖基转移酶和肿瘤微环境。最后，本综述讨论了粘蛋白聚糖表位作为潜在诊断和治疗靶点的范围。
Mucins are large glycoproteins expressed on the epithelia that provide a protective barrier against harsh insults from toxins and pathogenic microbes. These glycoproteins are classified primarily as being secreted and membrane-bound; both forms are involved in pathophysiological functions including inflammation and cancer. The high molecular weight of mucins is attributed to their large polypeptide backbone that is extensively covered by glycan moieties that modulate the function of mucins and, hence, play an important role in physiological functions. Deregulation of glycosylation machinery during malignant transformation results in altered mucin glycosylation. This review describes the functional implications and pathobiological significance of altered mucin glycosylation in cancer. Further, this review delineates various factors such as glycosyltransferases and tumor microenvironment that contribute to dysregulation of mucin glycosylation during cancer. Finally, this review discusses the scope of mucin glycan epitopes as potential diagnostic and therapeutic targets.