Targeting Immune Cell Checkpoints during Sepsis.
Targeting Immune Cell Checkpoints during Sepsis.
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DOI：
10.3390/ijms18112413
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发表时间：
2017-11-14
影响因子：
5.6
通讯作者：
Sherwood ER
中科院分区：
文献类型：
--
作者：
Patil NK;Guo Y;Luan L;Sherwood ER
Immunosuppression is increasingly being recognized as one of the causes of increased morbidity and mortality during sepsis. Both innate and adaptive immune system dysfunction have been shown to cause an impaired ability to eradicate the primary infection and also lead to frequent occurrence of secondary opportunistic infections. Pre-clinical and clinical studies have shown that inhibitory immune checkpoint molecules, including programmed death-1 (PD-1), programmed death ligand-1 (PD-L1), cytotoxic T lymphocyte antigen-4 (CTLA-4), T cell membrane protein-3 (TIM-3), Lymphocyte activation-gene-3 (LAG-3) and 2B4, are upregulated during the course of sepsis. Engagement of these inhibitory molecules on various immune cells has been consistently shown to inhibit innate immune cell functions (e.g., phagocytosis, cytokine production and pathogen clearance) and also lead to impaired T cell competence. In numerous pre-clinical models of sepsis, therapeutic agents aimed at blocking engagement of inhibitory immune checkpoints on immune cells have been shown to improve innate and adaptive immune cell functions, increase host resistance to infection and significantly improve survival. Therefore, immunotherapy with immune cell checkpoint inhibitors holds significant potential for the future of sepsis therapy and merits further investigation.
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DOI：
10.1186/cc10112
发表时间：
2011
期刊：
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影响因子：
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2017-09-15
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影响因子：
12.3
作者：
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通讯作者：
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DOI：
10.4049/jimmunol.1302252
发表时间：
2014-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Huang X;Chen Y;Chung CS;Yuan Z;Monaghan SF;Wang F;Ayala A
通讯作者：
Ayala A
影响因子：
120.7
作者：
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