Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations.
Use of Capsaicin to Treat Pain: Mechanistic and Therapeutic Considerations.
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DOI：
10.3390/ph9040066
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发表时间：
2016-11-01
期刊：
影响因子：
--
通讯作者：
Campbell JN
中科院分区：
文献类型：
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作者：
Chung MK;Campbell JN
辣椒素是辣椒的辛辣成分，被批准用于局部治疗神经性疼痛。单次治疗后镇痛效果可持续数月。辣椒素选择性激活 TRPV1，这是一种可渗透 Ca2+ 的阳离子离子通道，富含某些伤害感受器的末端。激活后，对有害刺激的反应会长期减弱。人们还对使用注射辣椒素治疗局灶性疼痛病症（例如关节炎和其他肌肉骨骼病症）感兴趣。最近，注射辣椒素对莫顿神经瘤患者显示出治疗效果，莫顿神经瘤是一种与其中一根指神经受压有关的足部疼痛疾病。疼痛的缓解与触觉的变化无关。尽管注射会引起短期疼痛，但短暂的全身暴露和在没有其他感觉变化的情况下建立长期镇痛的潜力创造了有吸引力的临床特征。短期和长期影响是由伤害性末梢的功能和结构变化引起的。在这篇综述中，我们讨论了局部施用辣椒素如何引起伤害性末梢消融及其临床意义。
Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment of neuropathic pain. The analgesia lasts for several months after a single treatment. Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel that is enriched in the terminals of certain nociceptors. Activation is followed by a prolonged decreased response to noxious stimuli. Interest also exists in the use of injectable capsaicin as a treatment for focal pain conditions, such as arthritis and other musculoskeletal conditions. Recently injection of capsaicin showed therapeutic efficacy in patients with Morton’s neuroma, a painful foot condition associated with compression of one of the digital nerves. The relief of pain was associated with no change in tactile sensibility. Though injection evokes short term pain, the brief systemic exposure and potential to establish long term analgesia without other sensory changes creates an attractive clinical profile. Short-term and long-term effects arise from both functional and structural changes in nociceptive terminals. In this review, we discuss how local administration of capsaicin may induce ablation of nociceptive terminals and the clinical implications.