Comparison of epicardial, abdominal and regional fat compartments in response to weight loss
Comparison of epicardial, abdominal and regional fat compartments in response to weight loss
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DOI：
10.1016/j.numecd.2009.01.010
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发表时间：
2009-12-01
影响因子：
3.9
通讯作者：
Ajisaka, R.
中科院分区：
文献类型：
--
作者：
Kim, M. -K.;Tanaka, K.;Ajisaka, R.
背景和目的：超声心动图测量心外膜脂肪（EF）似乎是一种可靠的诊断内脏脂肪的指标。脂肪组织（VAT）。然而，体重减轻引起的EF变化尚未与VAT或躯干的变化进行比较。仓库。在这项研究中，我们的目的是比较减肥引起的EF，VAT和其他区域的脂肪compartments.Methods和结果的变化：在这项研究中，27名中度肥胖的男性（年龄45.8 +/- 1.7岁;体重指数30.5 +/- 0.7 kg/m2）遵循每日低热量饮食作为临床的一部分。12-一周减肥干预。study.我们通过经胸超声心动图评估EF厚度，通过计算机断层扫描评估腹部脂肪组织，并通过双能X线吸收法检查区域和全身脂肪室。初始热量摄入平均减少26.8%，对应于EF厚度（P < 0.001）、体重、脂肪质量百分比和腹部脂肪室分别减少17.2%、11.0%、16.6%和29.8%。增值税的百分比变化，以响应体重减轻是两倍高的实质性。结论：低热量饮食引起的体重波动降低了EF厚度。仅中度饮食诱导的体重减轻可能代表了降低EF的有效非药物策略，EF是一种独特的致病性脂肪储存库，也是一种新兴的VAT标志物。(c)2009 Elsevier B. V.保留所有权利。
Background and aims: Echocardiographic measurement of epicardial fat (EF) seems to be a reliable and diagnostic marker of visceral. adipose tissue (VAT). However, the weight loss-induced changes in EF have not been compared with those in VAT or the truncal. depot. In this study, we aimed to compare the weight loss-induced changes in EF, VAT and other regional fat compartments in obese men.Methods and results: In this study, 27 moderately obese men (age 45.8 +/- 1.7 years; body mass index 30.5 +/- 0.7 kg/m(2)) followed a daily low-calorie diet as part of a clinical. 12-week weight loss interventional. study. We evaluated the EF thickness by transthoracic echocardiography, assessed the abdominal fat tissues by computed tomography scans, and examined the regional and whole body fat compartments by dual X-ray absorptiometry. An average decrease of 26.8% in the initial calorie intake corresponded to post-program reductions of 17.2%, 11.0%, 16.6%, and 29.8% in EF thickness (P < 0.001), body mass, percentage fat mass, and abdominal fat compartments, respectively. The percentage change in VAT in response to weight loss was twice as high as the substantial. change in EF tissue (P < 0.001).Conclusion: The results of the study suggest that a low-calorie diet-induced weight toss decreases EF thickness. Moderate diet-induced weight loss alone may represent an effective nonpharmacological strategy for reducing EF, which is a unique, pathogenic fat depot and an emerging marker of VAT. (c) 2009 Elsevier B.V. All rights reserved.