UNUSUAL TRIHYDROXY BILE-ACIDS IN THE URINE OF PATIENTS TREATED WITH CHENODEOXYCHOLATE, URSODEOXYCHOLATE OR RIFAMPICIN AND THOSE WITH CIRRHOSIS
UNUSUAL TRIHYDROXY BILE-ACIDS IN THE URINE OF PATIENTS TREATED WITH CHENODEOXYCHOLATE, URSODEOXYCHOLATE OR RIFAMPICIN AND THOSE WITH CIRRHOSIS
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DOI：
10.1002/hep.1840110215
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发表时间：
1990-02-01
期刊：
影响因子：
13.5
通讯作者：
HASEGAWA, T
中科院分区：
文献类型：
--
作者：
NAKASHIMA, T;SANO, A;HASEGAWA, T
采用气液色谱和气液色谱-质谱联用技术分析了20例鹅去氧胆酸盐、18例熊去氧胆酸盐、15例利福平和8例晚期肝硬化患者的尿胆汁酸。三种所谓的不寻常的三羟基胆汁酸，猪胆酸盐、熊胆酸盐和ω-与未经治疗的健康成人相比，鹅去氧胆酸盐、熊去氧胆酸盐或利福平治疗的患者中，这些数据表明，鹅去氧胆酸盐和熊去氧胆酸盐被羟基化，在胆汁酸负荷人体中产生不寻常的三羟基胆汁酸，这种代谢可能与利福平诱导肝微粒体酶有关。相反，鹅去氧胆酸盐和熊去氧胆酸盐的羟基化可能会受到严重肝损伤的损害。因为尿液是内部胆汁酸的分泌途径，所以尿液中出现不寻常的三羟基胆汁酸可用作肝脏将“疏水”“二羟基胆汁酸代谢为其分泌形式的能力的指标。
Urinary bile acids from 20 patients treated with chenodeoxycholate, 18 treated with ursodeoxycholate, 15 treated with rifampicin and 8 patients with advanced cirrhosis were analyzed by gas-liquid chromatography and gas-liquid chromatography-mass spectrometry. Occurrence rates and amounts of three so-called unusual trihydroxy bile acids, hyocholate, ursocholate and .omega.-muricholate, were increased in patinets treated with chenodeoxycholate, ursodeoxycholate or rifampicin and decreased in cirrhotic patients as compared with those in untreated healthy adults. These data suggest that chenodeoxycholate and ursodeoxycholate are hydroxylated to produce unusual trihydroxy bile acids in bile acid-loaded humans and that this metabolism may be related to the induction of hepatic microsomal enzymes by rifampicin. In contrast, the hydroxylation of chenodeoxycholate and ursodeoxycholate may be impaired by severe hepatic damage. Because the urine is a secretory pathway for internal bile acids, the occurrence of unusual trihydroxy bile acids in the urine may be used as an indicator of hepatic ability to metabolize ''''hydrophobic'''' dihydroxy bile acids to their secretory forms.