Dietary l-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs
Dietary l-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs
复制标题
日粮补充 L-精氨酸可增加生长肥育猪的肌肉增益并减少体脂量
DOI：
10.1007/s00726-008-0148-0
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发表时间：
2009-05-01
期刊：
影响因子：
3.5
通讯作者：
Wu, Guoyao
中科院分区：
文献类型：
--
作者：
Tan, Bie;Yin, Yulong;Wu, Guoyao
人类肥胖是世界范围内的一个重大公共卫生危机。此外，牲畜物种在市场重量下表现出过量的皮下脂肪。然而，目前几乎没有减少哺乳动物肥胖的方法。本研究用猪模型进行，以检验膳食L-精氨酸补充剂可增加肌肉增加和减少脂肪沉积的假设。选用24头110日龄的公猪，随机分为两组，分别在玉米和豆粕基础日粮中添加1.0%L-精氨酸和2.05%L-丙氨酸（等氮对照）。根据体重增加和食物摄入量测量生长性能。经过60天的补充，胴体和肌肉成分进行了测量。与对照组相比，添加精氨酸的猪血清甘油三酯浓度降低了20%（P < 0.01），但胰高血糖素水平提高了36%（P < 0.05）。与对照组相比，添加精氨酸使增重提高6.5%（P < 0.05），胴体瘦肉率提高5.5%（P <0.05），胴体脂肪率降低11%（P < 0.01）。精氨酸处理使背最长肌蛋白质、糖原和脂肪含量分别增加4.8%、42%和70%（P < 0.05），肌肉pH值增加0.32，而肌肉乳酸含量减少37%。这些结果支持了我们的假设，即日粮中补充精氨酸有利于促进生长肥育猪的增肌和减少体脂的积累。这些发现对开发治疗人类肥胖和促进猪瘦肉组织生长的新疗法产生了积极影响。
Obesity in humans is a major public health crisis worldwide. In addition, livestock species exhibit excessive subcutaneous fat at market weight. However, there are currently few means of reducing adiposity in mammals. This study was conducted with a swine model to test the hypothesis that dietary L-arginine supplementation may increase muscle gain and decrease fat deposition. Twenty-four 110-day-old barrows were assigned randomly into two treatments, representing supplementation with 1.0% L-arginine or 2.05% L-alanine (isonitrogenous control) to a corn- and soybean meal-based diet. Growth performance was measured based on weight gain and food intake. After a 60-day period of supplementation, carcass and muscle composition were measured. Serum triglyceride concentration was 20% lower (P < 0.01) but glucagon level was 36% greater (P < 0.05) in arginine-supplemented than in control pigs. Compared with the control, arginine supplementation increased (P < 0.05) body weight gain by 6.5% and carcass skeletal-muscle content by 5.5%, while decreasing (P < 0.01) carcass fat content by 11%. The arginine treatment enhanced (P < 0.05) longissimus dorsi muscle protein, glycogen, and fat contents by 4.8, 42, and 70%, respectively, as well as muscle pH at 45 min post-mortem by 0.32, while reducing muscle lactate content by 37%. These results support our hypothesis that dietary arginine supplementation beneficially promotes muscle gain and reduces body fat accretion in growing-finishing pigs. The findings have a positive impact on development of novel therapeutics to treat human obesity and enhance swine lean-tissue growth.