Sex-specific functional adaptation of the femoral diaphysis to body composition
Sex-specific functional adaptation of the femoral diaphysis to body composition
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DOI：
10.1002/ajhb.23123
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发表时间：
2018-07-01
影响因子：
2.9
通讯作者：
Bruzek, Jaroslav
中科院分区：
文献类型：
--
作者：
Jeanson, Alize Lacoste;Santos, Frederic;Bruzek, Jaroslav
目的人类股骨干常用于重建负荷历史（活动性、活动性、体重）。已知股骨近端受总脂肪量（FM）、去脂肪量（FFM）和体脂百分比（BF%）变化的影响不同，但迄今为止，整个骨干对身体成分的适应性尚未得到充分表征。了解股骨干如何适应身体组件将有利于生物力学解释股骨的变化和营养相关的studies.MethodsCombining各种方法从临床营养，生物人类学，几何形态计量学，我们评估了相关性的措施，对整个股骨干估计FM，FFM，BF%从61 CT扫描（17名女性，44名男性）。样本主要是由人与obesity.ResultsCortical面积的横截面和局部皮质厚度表现出很高的相关性BF%，特别是在女性中。两种性别的曲率均随FM和BF%显著降低。最低的相关性被发现与FFM.ConclusionsThe观察到的性别二态性是一致的不同的老化过程;皮质骨减少女性通过骨内膜吸收，而它几乎保持不变的男性谁补偿骨内膜吸收骨膜附着在骨干表面。对压缩力的功能性适应表明，仅在女性中，骨材料的全身性骨内膜沉积增加BF%和FM。在两种性别中，FM和BF%均与较直的股骨相关，表明通过沿整个骨干沿着更线性地分布压缩载荷来优化压缩载荷抵抗力。
ObjectivesThe human femoral diaphysis is often used to reconstruct loading histories (mobility, activity, body mass). The proximal femur is known to be differentially affected by changes in total fat-mass (FM), fat-free mass (FFM), and body fat percentage (BF%), but the adaptation of the entire diaphysis to body composition has not been thoroughly characterized to date. Understanding how the femoral diaphysis adapts to body components would benefit biomechanical interpretations of the femoral variation and nutrition-related studies.MethodsCombining various methods from clinical nutrition, biological anthropology, and geometric morphometrics, we evaluated the correlation of measures taken on the entire femoral diaphysis with estimated FM, FFM, and BF% from 61 CT scans (17 females, 44 males). The sample was predominantly composed of people with obesity.ResultsCortical area of the cross-sections and local cortical thickness showed high correlation with BF% in particular, in females only. The curvature significantly decreased with FM and BF% in both sexes. The lowest correlations are found with FFM.ConclusionsThe observed sexual dimorphism is consistent with differing aging processes; cortical bone decreases in females through endosteal resorption while it remains almost constant in males who compensate for endosteal resorption by periosteal apposition on the diaphyseal surface. The functional adaptation to compressive forces indicates a systemic endosteal apposition of bone material with increased BF% and FM in females only. FM and BF% are linked to a straighter femur in both sexes, suggesting an optimization of the resistance to compressive loads by distributing them more linearly along the entire diaphysis.