Guiding principles in the design of molecular bioconjugates for vaccine applications.
Guiding principles in the design of molecular bioconjugates for vaccine applications.
复制标题
DOI：
10.1021/acs.bioconjchem.5b00103
复制
发表时间：
2015-05-20
影响因子：
4.7
通讯作者：
Irvine DJ
中科院分区：
文献类型：
--
作者：
Liu H;Irvine DJ
基于抗原和佐剂的生物结合物可以刺激免疫系统，在疫苗应用中发挥着重要作用。生物偶联物表现出独特的物理化学和生物学特性，使疫苗能够被输送到关键的免疫细胞，靶向特定的细胞内途径，或模仿自然病原体的免疫原性。在这篇综述中，我们重点介绍了这类分子免疫调节剂的最新进展，重点介绍了为合理设计安全有效的疫苗和免疫疗法提供基础的结构-功能关系。
Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure-function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.