Effects of fluoride- and chlorhexidine-containing varnishes on plaque composition and on demineralization of dentinal grooves in situ.
Effects of fluoride- and chlorhexidine-containing varnishes on plaque composition and on demineralization of dentinal grooves in situ.
复制标题
含氟化物和氯己定的清漆对牙菌斑成分和牙本质沟原位脱矿质的影响。
DOI：
10.1034/j.1600-0722.2000.00779.x
复制
发表时间：
2000
影响因子：
1.9
通讯作者：
J. M. ten Cate
中科院分区：
文献类型：
--
作者：
E. Zaura;J. M. ten Cate
该研究的目的是比较Cervitec（含1%氯己定和1%百里香酚）、Fluor Protector（含0.1%氟化物）和安慰剂清漆（1:1混合物）对菌斑中变形链球菌和乳酸菌百分比的影响，以及对潜在牙本质脱矿的影响，通过显微放射照相进行评估。牛牙本质盘装有三个平行凹槽，在第一个凹槽和牙本质表面邻近部分接受其中一种清漆处理。志愿者（n = 23）连续4周将椎间盘固定在局部义齿上。菌斑的微生物分析显示，两组之间没有差异。氟化物清漆（氟保护剂和混合清漆）对处理槽中矿物质流失的抑制作用明显大于Cervitec或安慰剂。所有治疗清漆在脱矿程度较高的小组成员（n = 14）中有更明显的效果（安慰剂组的矿物质损失>或= 1200 vol% x microm）。在这些小组成员中，含chx的清漆对所有凹槽的脱矿都有抑制作用，在两个未清漆的凹槽中也是如此。氟化物清漆对脱矿的局部效果最大，CHX清漆对脱矿的外周效果最大，因此在易患龋的人群中，联合治疗是获得最佳防龋效果的首选方法。
The aim of the study was to compare the effects of Cervitec, containing 1% chlorhexidine (CHX) and 1% thymol, Fluor Protector, containing 0.1% fluoride, their 1:1 mixture, and a placebo varnish on the percentage of mutans streptococci and lactobacilli in plaque and on the underlying dentin demineralization, as assessed by microradiography. Bovine dentine discs, fitted with three parallel grooves, received one of the varnish treatments into the first groove and on the adjacent part of the dentin surface. Volunteers (n = 23) wore the discs fixed to their partial dentures for four consecutive 3 wk periods. Microbiological analysis of plaque accumulated in the grooves showed no difference between groups. Fluoride varnishes (Fluor Protector and mixed varnish) had a significantly larger inhibitory effect on mineral loss in the treated groove than Cervitec or placebo. All treatment varnishes had more pronounced effect in panelists (n = 14) with higher degree of demineralization (mineral loss in placebo group > or = 1,200 vol% x microm). In these panelists, CHX-containing varnishes showed an inhibitory effect on demineralization in all grooves, also in the two non-varnished grooves. As fluoride varnishes had the largest localized effect on demineralization, and CHX varnishes were showing a peripheral effect, a combined treatment could be the preferred method to obtain an optimal caries preventive effect in caries-prone individuals.