Prevalence and genotypes of alpha- and beta-thalassemia carriers in Hong Kong - Implications for population screening
Prevalence and genotypes of alpha- and beta-thalassemia carriers in Hong Kong - Implications for population screening
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DOI：
10.1056/nejm199705013361805
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发表时间：
1997-05-01
影响因子：
158.5
通讯作者：
Chui, DHK
中科院分区：
文献类型：
--
作者：
Lau, YL;Chan, LC;Chui, DHK
地中海贫血在中国南方很常见。我们确定了这些遗传性疾病的杂合子携带者在香港的患病率和评估的可行性，以社区为基础的筛查programme.Methods的地中海贫血症的教育和筛查计划进行了三所高中，共2420名学生。75%的学生同意接受筛查，包括血细胞计数，血红蛋白电泳，血清铁蛋白测量和DNA分析。结果在1800份血样中，150份（8.3%）有小红细胞症（平均红细胞体积，
Background The thalassemias are common in southern China. We determined the prevalence of heterozygous carriers of these genetic disorders in Hang Kong and assessed the feasibility of a community-based screening program.Methods An educational and screening program far the thalassemias was carried out in three high schools with a total of 2420 students. Seventy-five percent of the students agreed to undergo screening, which consisted of blood counts, hemoglobin electrophoresis, serum ferri tin measurements, and DNA analyses.Results Of the 1800 blood samples tested, 150 (8.3 percent) had microcytosis (mean corpuscular volume,