ANTIENDOTOXIN HUMAN MONOCLONAL-ANTIBODY A6H4C5 (HA-1A) UTILIZES THE VH4.21 GENE
ANTIENDOTOXIN HUMAN MONOCLONAL-ANTIBODY A6H4C5 (HA-1A) UTILIZES THE VH4.21 GENE
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DOI：
10.1093/clinids/21.supplement_2.s186
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发表时间：
1995-10-01
影响因子：
11.8
通讯作者：
TENG, NNH
中科院分区：
文献类型：
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作者：
BIEBER, MM;BHAT, NM;TENG, NNH
人 IgM 单克隆抗体 A6H4C5 由 Centocor (Malvern, PA) 生产，并作为 HA-1A (Centoxin) 用于临床试验。在体外，A6H4C5 与脂质 A 和粗菌株、革兰氏阴性菌内毒素结合。对 A6H4C5 的进一步分析表明，它是一种多反应性冷凝集素，利用种系配置中的 VH4.21 基因片段。它也是一种与人类 B 细胞结合的人类抗体。我们已经表征了其他几种独立衍生的 VH4.21 人单克隆抗体，其特征与 A6H4C5 相同。这组抗体可能代表保守的宿主免疫反应。
Human IgM monoclonal antibody A6H4C5 was manufactured by Centocor (Malvern, PA) and used in clinical trials as HA-1A (Centoxin). In vitro, A6H4C5 binds to lipid A and rough-strain, gram-negative bacteria endotoxin. Further analysis of A6H4C5 has shown that it is a polyreactive, cold agglutinin that utilizes the VH4.21 gene segment in germline configuration. It is also a human antibody that binds to human B cells. We have characterized several other independently derived VH4.21 human monoclonal antibodies with the same characteristics as A6H4C5. This group of antibodies may represent a conserved host immune response.