The Type VI secretion system: a versatile bacterial weapon
The Type VI secretion system: a versatile bacterial weapon
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DOI：
10.1099/mic.0.000789
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发表时间：
2019-05-01
期刊：
影响因子：
2.8
通讯作者：
Coulthurst, Sarah
中科院分区：
文献类型：
--
作者：
Coulthurst, Sarah
VI型分泌系统（T6SS）是一种广泛存在于革兰氏阴性细菌中的蛋白质纳米机器，用于将效应蛋白直接转移到邻近细胞中。它代表了一种多功能细菌武器，可以将效应器传递到不同类别的靶细胞中，在细菌间竞争以及细菌与真核细胞的相互作用中发挥关键作用。这种多功能性的基础是 T6SS 能够传递大量效应蛋白，具有许多不同的活性和与分泌机制相互作用的模式。最近的工作强调了多微生物群落内 T6SS 介导的相互作用的重要性和多样性，并为靶细胞中的效应器传递和作用提供了新的分子见解。
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-negative bacteria and is used to translocate effector proteins directly into neighbouring cells. It represents a versatile bacterial weapon that can deliver effectors into distinct classes of target cells, playing key roles in inter-bacterial competition and bacterial interactions with eukaryotic cells. This versatility is underpinned by the ability of the T6SS to deliver a vast array of effector proteins, with many distinct activities and modes of interaction with the secretion machinery. Recent work has highlighted the importance and diversity of interactions mediated by T6SSs within polymicrobial communities, and offers new molecular insights into effector delivery and action in target cells.