Extreme hyperbilirubinaemia in term and near-term infants in Denmark
Extreme hyperbilirubinaemia in term and near-term infants in Denmark
复制标题
DOI：
10.1080/08035250410022170
复制
发表时间：
2005-01-01
期刊：
影响因子：
3.8
通讯作者：
Schaarup, J
中科院分区：
文献类型：
--
作者：
Ebbesen, F;Andersson, C;Schaarup, J
目的：确定在足月或近足月出生的婴儿中极端高胆红素血症的发生率，即。未结合胆红素的血清浓度超过限值，根据授权指南，高于该限值时需要进行换血。方法：调查时间为2000年1月1日~ 2001年12月31日，历时2年.包括丹麦所有足月或近足月活产婴儿。记录了儿科收治的所有患有极度高胆红素血症的婴儿。结果：32名婴儿出现极高胆红素血症。也就是说，发病率为十万分之二十五。最大血清总胆红素浓度（TSB）为492（385-689）mumol/l（中位数（范围））。换血限值的中位数为450 mumol/l。12名婴儿有中枢神经系统受累的体征和症状; 11名有急性胆红素脑病1期症状; 1名有2期症状。19名婴儿在产科病房或新生儿科初次入院时发生了极度高胆红素血症：另一名婴儿在出院后发生。未出院的婴儿和从家中入院的婴儿之间的最大TSB没有差异。最大TSB出现在从家中入院的婴儿中最晚（p
Aim: To determine the incidence amongst infants born at term or near-term of extreme hyperbilirubinaemia, i.e.. with a serum concentration of unconjugated bilirubin exceeding the limit above which an exchange transfusion was indicated according to the authorized guidelines. Method: The investigation period covered 2 y, 1 January 2000 to 31 December 2001. and included all infants born alive at term or near-term in Denmark. All infants with extreme hyperbilirubinaemia admitted to paediatric departments were recorded. Results: Thirty-two infants developed extreme hyperbdirubinaemia. i.e., an incidence of 25 per 100 000. The maximum total serum bilirubin concentration (TSB) was 492 (385-689) mumol/l (median (range)). The median value of the exchange transfusion limits was 450 mumol/l. Twelve infants had signs and symptoms of central nervous system involvement; 11 had acute bilirubin encephalopathy phase-1 symptoms; and one had phase-2 symptoms. Nineteen infarits developed extreme hyperbilirubinaemia during primary admission to the maternity ward or neonatal department: the other-after having been discharged. There was no difference in maximum TSB between those infants not discharged from hospital and those infants admitted to hospital from home. Maximum TSB appeared latest amongst those infants admitted from home (p