The Effects of Δ9-Tetrahydrocannabinol on Action Potentials in the Mollusc Aplysia
The Effects of Δ9-Tetrahydrocannabinol on Action Potentials in the Mollusc Aplysia
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Δ9-四氢大麻酚对海兔动作电位的影响
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
Ronald Chase
中科院分区：
文献类型：
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作者：
J. Acosta;Ronald Chase
在体内记录的过程中，研究了Δ9-四氢大麻酚（Δ9-THC）对离体的加利福尼亚蟾蜍颊神经节和顶内脏神经节动作电位的影响。当将该化合物加入到浸泡制剂的盐溶液中时，该化合物（浓度为10−4-10−5 M）导致尖峰过冲（总振幅的15-20%）减少，并增加了对电刺激的反应的不稳定性。 体细胞膜似乎比轴突膜更受影响。神经节中的扩散屏障可能是药物反应高度变异性的原因，因此仅在约30%的测试中观察到这两种特征性变化。这是首次报道Δ9-THC对无脊椎动物神经元的影响。结果表明，Δ9-THC导致神经细胞兴奋性的抑制，并且这些数据与THC化合物在哺乳动物中的报道效果一致。
The effects of Δ9-tetrahydrocannabinol (Δ9-THC) on action potentials were examined during intrasomatic recordings from the isolated buccal and parieto–visceral ganglia of Aplysia californica. When added to the saline solution bathing the preparation, the compound (in concentrations 10−4–10−5 M) caused a reduction in spike overshoot (15–20% of total amplitude) and increased the lability of responses to electrical stimulation. The somatic membrane appeared to be more affected than the axonal membrane. Diffusion barriers in the ganglion probably account for the high degree of variability in drug response, such that both of the characteristic changes were observed in only about 30% of the tests. This is the first report to describe effects of Δ9-THC on invertebrate neurones. The results indicate that Δ9-THC causes a depression in nerve cell excitability, and these data are consistent with reported effects of THC compounds in mammals.