The isolation and crystal structure of a cyclic selenenate ester derived from Bis(2,6-diformyl-4-tert-butylphenyl)diselenide and its glutathione peroxidase-like activity.
The isolation and crystal structure of a cyclic selenenate ester derived from Bis(2,6-diformyl-4-tert-butylphenyl)diselenide and its glutathione peroxidase-like activity.
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双(2,6-二甲酰基-4-叔丁基苯基)二硒化物衍生的环状硒酸酯的分离和晶体结构及其谷胱甘肽过氧化物酶样活性。
DOI：
10.1002/anie.200460380
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发表时间：
2004
影响因子：
--
通讯作者：
R. Butcher
中科院分区：
文献类型：
--
作者：
Sanjio S. Zade;Harkesh B. Singh;R. Butcher
酶模拟：二硒化物 1 的卤化通过高度不稳定的硒酸中间体提供环状硒酸酯 2（参见方案）。 Compound 2 exhibits a strong intramolecular nonbonding Se···O interaction. 1和2均表现出优异的谷胱甘肽过氧化物酶样催化活性。
Enzyme mimicry: Halogenation of diselenide 1 affords the cyclic selenenate ester 2 (see scheme) through a highly unstable selenenic acid intermediate. Compound 2 exhibits a strong intramolecular nonbonding Se···O interaction. Both 1 and 2 show excellent glutathione peroxidase-like catalytic activity.