Chronic postsurgical pain in Europe An observational study
Chronic postsurgical pain in Europe An observational study
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DOI：
10.1097/eja.0000000000000319
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发表时间：
2015-10-01
影响因子：
3.6
通讯作者：
Meissner, Winfried
中科院分区：
文献类型：
--
作者：
Fletcher, Dominique;Stamer, Ulrike M.;Meissner, Winfried
背景慢性术后疼痛（CPSP）是一个重要的临床问题。需要对 CPSP 的发病率、特征和危险因素进行前瞻性研究。目的本研究的目的是评估 CPSP 的发病率和危险因素。设计多中心、前瞻性、观察性试验。设置欧洲 11 个国家的 21 家医院。患者 3120 名接受手术并在欧洲注册中心登记的患者。主要结果指标在术后第一次评估疼痛相关结果天 (D1) 使用标准化疼痛结果问卷。 6 个月和 12 个月时通过电子邮件或电话访谈进行回顾，使用简短疼痛量表 (BPI) 和 DN4（Douleur Neuropathique 四个问题）。主要终点是 12 个月时中度至重度 CPSP 的发生率（数字评分量表，NRS 3/10）。 结果 对于 1044 名和 889 名患者，在 6 个月和 12 个月时可获得完整数据。 12 个月时，中度至重度 CPSP 的发生率为 11.8%（95% CI 9.7 至 13.9），重度疼痛（NRS 6）的发生率为 2.2%（95% CI 1.2 至 3.3）。中度和重度 CPSP 患者的神经性疼痛体征分别为 35.4%（95% CI 23.9 至 48.3）和 57.1%（95% CI 30.7 至 83.4）。 6 个月和 12 个月时的功能障碍 (BPI) 随着 CPSP 的严重程度而增加 (P
BACKGROUNDChronic postsurgical pain (CPSP) is an important clinical problem. Prospective studies of the incidence, characteristics and risk factors of CPSP are needed.OBJECTIVESThe objective of this study is to evaluate the incidence and risk factors of CPSP.DESIGNA multicentre, prospective, observational trial.SETTINGTwenty-one hospitals in 11 European countries.PATIENTSThree thousand one hundred and twenty patients undergoing surgery and enrolled in the European registry PAIN OUT.MAIN OUTCOME MEASURESPain-related outcome was evaluated on the first postoperative day (D1) using a standardised pain outcome questionnaire. Review at 6 and 12 months via e-mail or telephonic interview used the Brief Pain Inventory (BPI) and the DN4 (Douleur Neuropathique four questions). Primary endpoint was the incidence of moderate to severe CPSP (numeric rating scale, NRS 3/10) at 12 months.RESULTSFor 1044 and 889 patients, complete data were available at 6 and 12 months. At 12 months, the incidence of moderate to severe CPSP was 11.8% (95% CI 9.7 to 13.9) and of severe pain (NRS 6) 2.2% (95% CI 1.2 to 3.3). Signs of neuropathic pain were recorded in 35.4% (95% CI 23.9 to 48.3) and 57.1% (95% CI 30.7 to 83.4) of patients with moderate and severe CPSP, respectively. Functional impairment (BPI) at 6 and 12 months increased with the severity of CPSP (P