"Impoverished" and "enriched" living conditions influence the proliferation and survival of neurons in crayfish brain
"Impoverished" and "enriched" living conditions influence the proliferation and survival of neurons in crayfish brain
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DOI：
10.1002/1097-4695(200012)45:4
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发表时间：
2000-12-01
期刊：
影响因子：
--
通讯作者：
Sandeman, D
中科院分区：
文献类型：
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作者：
Sandeman, R;Sandeman, D
在小龙虾的一生中，新的神经元被添加到小龙虾大脑中的两个双边神经元簇中。这些中间神经元与嗅觉叶和副叶相关，嗅觉叶和副叶是从视觉和触觉受体系统接收初级嗅觉信息和高阶输入的大脑区域。在这四个集群中的细胞增殖率，揭示了BrdU标记，是敏感的动物的生活条件：在小空间（贫困条件）的个人孤立表现出较低的细胞增殖率相比，他们的兄弟姐妹一起生活在更大的地区（丰富的条件），虽然这两个群体都喂饱。增殖速率的降低可以在动物经受贫乏条件后1至2周测量。在两种条件下生存1周后存活的标记神经元的计数表明，与生活在丰富条件下的兄弟姐妹相比，在贫困条件下生活2周的动物大脑中存活的新神经元较少。诸如表面积、水深和社会互动等因素都可以在确定淡水小龙虾的新神经元产生速率和将新神经元纳入大脑中方面发挥作用，结果表明小龙虾大脑中高度的神经元可塑性对动物保持的条件高度敏感。(C)2000年约翰·威利父子公司。Inc.
New neurons are added to two bilateral clusters of neurons in crayfish brain throughout their lives. These interneurons are associated with the olfactory and accessory lobes, areas of the brain that receive primary olfactory information and higher order Inputs from the visual and tactile receptor systems. The rate of cell proliferation in these four clusters, revealed by BrdU labeling, is sensitive to the living conditions of the animals: individuals isolated in small spaces (impoverished condition) exhibit a lower rate of cell proliferation in comparison to their siblings living together in larger areas (enriched condition), although both groups were fed to satiation. Reduction in the rate of proliferation can he measured 1 to 2 weeks after the animals are subjected to the impoverished condition. Counts of the labeled neurons that survive after 1 weeks of subjection to the two conditions show that fewer new neurons survive in the brains of animals that have lived for 2 weeks in the impoverished condition in comparison to their siblings living in the enriched conditions. Factors such as surface area, depth of water, and social interaction can all play a role in determining both the rate of new neuron production and the incorporation of the new neurons into the brain of freshwater crayfish, The results indicate a high degree of neuronal plasticity in the crayfish brain that is highly sensitive to the conditions under which the animals are kept. (C) 2000 John Wiley & Sons. Inc.