Prior DNA vaccination does not interfere with the live-attenuated measles vaccine.
Prior DNA vaccination does not interfere with the live-attenuated measles vaccine.
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先前的 DNA 疫苗接种不会干扰麻疹减毒活疫苗。
DOI：
10.1016/j.vaccine.2003.08.020
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发表时间：
2004
期刊：
影响因子：
5.5
通讯作者：
McChesney,Michael
中科院分区：
文献类型：
--
作者：
Premenko-Lanier,Mary;Rota,Paul;Rhodes,Gary;Bellini,William;McChesney,Michael
目前使用的麻疹减毒活疫苗非常有效，尽管母体抗体会阻止其在 6 个月大之前接种。我们正在研究编码麻疹病毒血凝素、融合蛋白和核蛋白的 DNA 疫苗保护新生儿免受麻疹感染的能力。在这里，我们证明麻疹 DNA 疫苗可以保护幼年猕猴免受致病性麻疹病毒的攻击，并且用这种 DNA 疫苗进行初免和加强的猕猴在接种犬瘟热麻疹减毒活疫苗后具有记忆消除抗体和细胞介导的反应。因此，给新生儿注射这种DNA疫苗可能不会妨碍麻疹减毒活疫苗的后续使用。
The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we show that a measles DNA vaccine protects juvenile macaques from pathogenic measles virus challenge and that macaques primed and boosted with this DNA vaccine have anemnestic antibody and cell-mediated responses after vaccination with a live-attenuated canine distemper-measles vaccine. Therefore, this DNA vaccine administered to newborn infants may not hinder the subsequent use of live-attenuated measles vaccine.