The TMS Map Scales with Increased Stimulation Intensity and Muscle Activation.
The TMS Map Scales with Increased Stimulation Intensity and Muscle Activation.
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DOI：
10.1007/s10548-015-0447-1
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发表时间：
2016-01
期刊：
影响因子：
2.7
通讯作者：
Grey MJ
中科院分区：
文献类型：
--
作者：
van de Ruit M;Grey MJ
研究皮质组织或其重组的一种方法是使用经颅磁刺激（TMS）来构建皮质脊髓兴奋性图。据报道，经颅磁刺激图是在多种刺激强度和肌肉激活水平下获得的。虽然已知mep会随着刺激强度和肌肉激活而增加，但这些因素对地图重心（COG）、面积、体积和形状的影响仍有待确定。因此，本研究的目的是系统地检查刺激强度和肌肉激活对这四个关键地图结果测量的影响。在第一个实验中，以静息阈值的110%、120%和130%的刺激强度获得脑电图。在第二个实验中，在静止和最大自愿收缩的5,10,20和40%时获得地图。随着刺激强度的增加（P < 0.01）和肌肉激活度的增加（P < 0.01），脑图面积和脑图体积均增加。无论是刺激强度还是肌肉激活，COG和地图形状都没有改变（P < 0.05）。这一结果表明，该地图只是根据刺激强度和肌肉激活程度进行缩放。
One way to study cortical organisation, or its reorganisation, is to use transcranial magnetic stimulation (TMS) to construct a map of corticospinal excitability. TMS maps are reported to be acquired with a wide variety of stimulation intensities and levels of muscle activation. Whilst MEPs are known to increase both with stimulation intensity and muscle activation, it remains to be established what the effect of these factors is on the map’s centre of gravity (COG), area, volume and shape. Therefore, the objective of this study was to systematically examine the effect of stimulation intensity and muscle activation on these four key map outcome measures. In a first experiment, maps were acquired with a stimulation intensity of 110, 120 and 130 % of resting threshold. In a second experiment, maps were acquired at rest and at 5, 10, 20 and 40 % of maximum voluntary contraction. Map area and map volume increased with both stimulation intensity (P < 0.01) and muscle activation (P < 0.01). Neither the COG nor the map shape changed with either stimulation intensity or muscle activation (P > 0.09 in all cases). This result indicates the map simply scales with stimulation intensity and muscle activation.