ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis
ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis
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DOI：
10.1038/embor.2013.112
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发表时间：
2013-09-01
期刊：
影响因子：
7.7
通讯作者：
Umeda, Masaaki
中科院分区：
文献类型：
--
作者：
Yoshiyama, Kaoru O.;Kobayashi, Junya;Umeda, Masaaki
拟南芥SOG1(Gamma Response 1抑制因子)是一种植物特有的转录因子，控制DNA损伤反应。在这里，我们报道SOG1被磷酸化以响应DNA损伤，并且这种磷酸化是由传感器激酶共济失调毛细血管扩张突变(ATM)介导的。我们发现SOG1的磷酸化对于DNA损伤的应答是至关重要的，包括下游基因的转录诱导，细胞分裂的瞬时停止和细胞的程序性死亡。虽然SOG1和哺乳动物肿瘤抑制基因P53的氨基酸序列没有相似之处，但本研究表明ATM介导的转录因子的磷酸化在植物和哺乳动物的DNA损伤反应中都起着关键作用。
Arabidopsis SOG1 (suppressor of gamma response 1) is a plant-specific transcription factor that governs the DNA damage response. Here we report that SOG1 is phosphorylated in response to DNA damage, and that this phosphorylation is mediated by the sensor kinase ataxia telangiectasia mutated (ATM). We show that SOG1 phosphorylation is crucial for the response to DNA damage, including transcriptional induction of downstream genes, transient arrest of cell division and programmed cell death. Although the amino-acid sequences of SOG1 and the mammalian tumour suppressor p53 show no similarity, this study demonstrates that ATM-mediated phosphorylation of a transcription factor has a pivotal role in the DNA damage response in both plants and mammals.